The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
Аутори
Đurašević, Siniša![](/themes/MirageCherry/images/orcid.png)
Stojković, Maja
![](/themes/MirageCherry/images/orcid.png)
Sopta, Jelena
Pavlović, Slađan Z.
![](/themes/MirageCherry/images/orcid.png)
Borković-Mitić, Slavica S.
![](/themes/MirageCherry/images/orcid.png)
Ivanović, Anđelija
Jasnić, Nebojša
![](/themes/MirageCherry/images/orcid.png)
Tosti, Tomislav
![](/themes/MirageCherry/images/orcid.png)
Đurović, Saša
![](/themes/MirageCherry/images/orcid.png)
Popović-Đorđević, Jelena
![](/themes/MirageCherry/images/orcid.png)
Todorović, Zoran B.
![](/themes/MirageCherry/images/orcid.png)
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/d...ehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.
Извор:
Scientific Reports, 2021, 11, 1, 1305-Издавач:
- Springer Nature
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200178 (Универзитет у Београду, Биолошки факултет) (RS-MESTD-inst-2020-200178)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200051 (Институт за општу и физичку хемију, Београд) (RS-MESTD-inst-2020-200051)
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4459
Повезане информације:
DOI: 10.1038/s41598-020-80011-y
ISSN: 2045-2322
WoS: 000626774100019
Scopus: 2-s2.0-85099371879
URI
https://www.nature.com/articles/s41598-020-80011-yhttps://cherry.chem.bg.ac.rs/handle/123456789/4458
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Đurašević, Siniša AU - Stojković, Maja AU - Sopta, Jelena AU - Pavlović, Slađan Z. AU - Borković-Mitić, Slavica S. AU - Ivanović, Anđelija AU - Jasnić, Nebojša AU - Tosti, Tomislav AU - Đurović, Saša AU - Popović-Đorđević, Jelena AU - Todorović, Zoran B. PY - 2021 UR - https://www.nature.com/articles/s41598-020-80011-y UR - https://cherry.chem.bg.ac.rs/handle/123456789/4458 AB - Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. PB - Springer Nature T2 - Scientific Reports T2 - Scientific ReportsSci Rep T1 - The effects of meldonium on the acute ischemia/reperfusion liver injury in rats VL - 11 IS - 1 SP - 1305 DO - 10.1038/s41598-020-80011-y ER -
@article{ author = "Đurašević, Siniša and Stojković, Maja and Sopta, Jelena and Pavlović, Slađan Z. and Borković-Mitić, Slavica S. and Ivanović, Anđelija and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Popović-Đorđević, Jelena and Todorović, Zoran B.", year = "2021", abstract = "Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.", publisher = "Springer Nature", journal = "Scientific Reports, Scientific ReportsSci Rep", title = "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats", volume = "11", number = "1", pages = "1305", doi = "10.1038/s41598-020-80011-y" }
Đurašević, S., Stojković, M., Sopta, J., Pavlović, S. Z., Borković-Mitić, S. S., Ivanović, A., Jasnić, N., Tosti, T., Đurović, S., Popović-Đorđević, J.,& Todorović, Z. B.. (2021). The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. in Scientific Reports Springer Nature., 11(1), 1305. https://doi.org/10.1038/s41598-020-80011-y
Đurašević S, Stojković M, Sopta J, Pavlović SZ, Borković-Mitić SS, Ivanović A, Jasnić N, Tosti T, Đurović S, Popović-Đorđević J, Todorović ZB. The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. in Scientific Reports. 2021;11(1):1305. doi:10.1038/s41598-020-80011-y .
Đurašević, Siniša, Stojković, Maja, Sopta, Jelena, Pavlović, Slađan Z., Borković-Mitić, Slavica S., Ivanović, Anđelija, Jasnić, Nebojša, Tosti, Tomislav, Đurović, Saša, Popović-Đorđević, Jelena, Todorović, Zoran B., "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats" in Scientific Reports, 11, no. 1 (2021):1305, https://doi.org/10.1038/s41598-020-80011-y . .