Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections
Само за регистроване кориснике
2021
Аутори
Dimkić, IvicaGobin, Ivana
Begić, Gabrijela
Repac Antić, Davorka
Ristivojević, Petar
Jurica, Karlo
Berić, Tanja
Lozo, Jelena
Abram, Maja
Stanković, Slaviša
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Antibacterial and antibiofilm efficacy through a synergistic effect of herbal leaf extracts of bearberry (BE), bearberry tea (BTE), parsley (PE), and the strawberry tree (STE) was evaluated to discover an alternative approach to control urinary tract infections caused by Enterococci. UHPLC–DAD MS/MS analysis indicated that herbal extracts were rich in ellagic and gallic acids, catechin, quercetin, and arbutin, which are strong antioxidants. Mostly, Enterococcus faecalis isolates showed resistance only to gentamicin and/or norfloxacin (26.3 %) and moderate biofilm production (31.5 %), while 12 isolates of Enterococcus faecium showed multiple antibiotic resistance. The minimum inhibitory concentration for the majority of isolates was 1.25 mg ml−1 for STE, but 2.5 mg ml−1 for BE and BTE. Although individual extracts gave higher MIC values, for most isolates, a synergistic effect at lower concentrations was achieved, when BE or BTE (0.625 mg ml−1) was combined with STE (0.31 mg ml−1). The ...BTE extract was shown to have the strongest individual effect on initial adhesiveness and on biofilm formation to all selected isolates, while the synergism of BTE and STE caused significant biofilm inhibition at all concentrations tested. The synergistic effect achieved of the tested extract combinations might be a starting point in the development of alternative products, effective against antibiotic resistant Enterococcus isolates.
Кључне речи:
Antibacterial effect / Biofilm inhibition / Herbal extracts / spp. / Synergistic effectИзвор:
Journal of Herbal Medicine, 2021, 28, 100445-Издавач:
- Elsevier GmbH
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200178 (Универзитет у Београду, Биолошки факултет) (RS-MESTD-inst-2020-200178)
- "Knowledge for progress and stability" (2016–2018)
- University of Rijeka, Croatia (Grants No. 13.06.2.2.60 and 13.06.1.1.07)
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4526
Повезане информације:
DOI: 10.1016/j.hermed.2021.100445
ISSN: 2210-8033
WoS: 000661371200001
Scopus: 2-s2.0-85103723566
URI
https://www.sciencedirect.com/science/article/pii/S2210803321000257https://cherry.chem.bg.ac.rs/handle/123456789/4525
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Dimkić, Ivica AU - Gobin, Ivana AU - Begić, Gabrijela AU - Repac Antić, Davorka AU - Ristivojević, Petar AU - Jurica, Karlo AU - Berić, Tanja AU - Lozo, Jelena AU - Abram, Maja AU - Stanković, Slaviša PY - 2021 UR - https://www.sciencedirect.com/science/article/pii/S2210803321000257 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4525 AB - Antibacterial and antibiofilm efficacy through a synergistic effect of herbal leaf extracts of bearberry (BE), bearberry tea (BTE), parsley (PE), and the strawberry tree (STE) was evaluated to discover an alternative approach to control urinary tract infections caused by Enterococci. UHPLC–DAD MS/MS analysis indicated that herbal extracts were rich in ellagic and gallic acids, catechin, quercetin, and arbutin, which are strong antioxidants. Mostly, Enterococcus faecalis isolates showed resistance only to gentamicin and/or norfloxacin (26.3 %) and moderate biofilm production (31.5 %), while 12 isolates of Enterococcus faecium showed multiple antibiotic resistance. The minimum inhibitory concentration for the majority of isolates was 1.25 mg ml−1 for STE, but 2.5 mg ml−1 for BE and BTE. Although individual extracts gave higher MIC values, for most isolates, a synergistic effect at lower concentrations was achieved, when BE or BTE (0.625 mg ml−1) was combined with STE (0.31 mg ml−1). The BTE extract was shown to have the strongest individual effect on initial adhesiveness and on biofilm formation to all selected isolates, while the synergism of BTE and STE caused significant biofilm inhibition at all concentrations tested. The synergistic effect achieved of the tested extract combinations might be a starting point in the development of alternative products, effective against antibiotic resistant Enterococcus isolates. PB - Elsevier GmbH T2 - Journal of Herbal Medicine T2 - Journal of Herbal MedicineJournal of Herbal Medicine T1 - Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections VL - 28 SP - 100445 DO - 10.1016/j.hermed.2021.100445 ER -
@article{ author = "Dimkić, Ivica and Gobin, Ivana and Begić, Gabrijela and Repac Antić, Davorka and Ristivojević, Petar and Jurica, Karlo and Berić, Tanja and Lozo, Jelena and Abram, Maja and Stanković, Slaviša", year = "2021", abstract = "Antibacterial and antibiofilm efficacy through a synergistic effect of herbal leaf extracts of bearberry (BE), bearberry tea (BTE), parsley (PE), and the strawberry tree (STE) was evaluated to discover an alternative approach to control urinary tract infections caused by Enterococci. UHPLC–DAD MS/MS analysis indicated that herbal extracts were rich in ellagic and gallic acids, catechin, quercetin, and arbutin, which are strong antioxidants. Mostly, Enterococcus faecalis isolates showed resistance only to gentamicin and/or norfloxacin (26.3 %) and moderate biofilm production (31.5 %), while 12 isolates of Enterococcus faecium showed multiple antibiotic resistance. The minimum inhibitory concentration for the majority of isolates was 1.25 mg ml−1 for STE, but 2.5 mg ml−1 for BE and BTE. Although individual extracts gave higher MIC values, for most isolates, a synergistic effect at lower concentrations was achieved, when BE or BTE (0.625 mg ml−1) was combined with STE (0.31 mg ml−1). The BTE extract was shown to have the strongest individual effect on initial adhesiveness and on biofilm formation to all selected isolates, while the synergism of BTE and STE caused significant biofilm inhibition at all concentrations tested. The synergistic effect achieved of the tested extract combinations might be a starting point in the development of alternative products, effective against antibiotic resistant Enterococcus isolates.", publisher = "Elsevier GmbH", journal = "Journal of Herbal Medicine, Journal of Herbal MedicineJournal of Herbal Medicine", title = "Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections", volume = "28", pages = "100445", doi = "10.1016/j.hermed.2021.100445" }
Dimkić, I., Gobin, I., Begić, G., Repac Antić, D., Ristivojević, P., Jurica, K., Berić, T., Lozo, J., Abram, M.,& Stanković, S.. (2021). Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections. in Journal of Herbal Medicine Elsevier GmbH., 28, 100445. https://doi.org/10.1016/j.hermed.2021.100445
Dimkić I, Gobin I, Begić G, Repac Antić D, Ristivojević P, Jurica K, Berić T, Lozo J, Abram M, Stanković S. Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections. in Journal of Herbal Medicine. 2021;28:100445. doi:10.1016/j.hermed.2021.100445 .
Dimkić, Ivica, Gobin, Ivana, Begić, Gabrijela, Repac Antić, Davorka, Ristivojević, Petar, Jurica, Karlo, Berić, Tanja, Lozo, Jelena, Abram, Maja, Stanković, Slaviša, "Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections" in Journal of Herbal Medicine, 28 (2021):100445, https://doi.org/10.1016/j.hermed.2021.100445 . .