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Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections

Authorized Users Only
2021
Authors
Dimkić, Ivica
Gobin, Ivana
Begić, Gabrijela
Repac Antić, Davorka
Ristivojević, Petar
Jurica, Karlo
Berić, Tanja
Lozo, Jelena
Abram, Maja
Stanković, Slaviša
Article (Published version)
Metadata
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Abstract
Antibacterial and antibiofilm efficacy through a synergistic effect of herbal leaf extracts of bearberry (BE), bearberry tea (BTE), parsley (PE), and the strawberry tree (STE) was evaluated to discover an alternative approach to control urinary tract infections caused by Enterococci. UHPLC–DAD MS/MS analysis indicated that herbal extracts were rich in ellagic and gallic acids, catechin, quercetin, and arbutin, which are strong antioxidants. Mostly, Enterococcus faecalis isolates showed resistance only to gentamicin and/or norfloxacin (26.3 %) and moderate biofilm production (31.5 %), while 12 isolates of Enterococcus faecium showed multiple antibiotic resistance. The minimum inhibitory concentration for the majority of isolates was 1.25 mg ml−1 for STE, but 2.5 mg ml−1 for BE and BTE. Although individual extracts gave higher MIC values, for most isolates, a synergistic effect at lower concentrations was achieved, when BE or BTE (0.625 mg ml−1) was combined with STE (0.31 mg ml−1). The ...BTE extract was shown to have the strongest individual effect on initial adhesiveness and on biofilm formation to all selected isolates, while the synergism of BTE and STE caused significant biofilm inhibition at all concentrations tested. The synergistic effect achieved of the tested extract combinations might be a starting point in the development of alternative products, effective against antibiotic resistant Enterococcus isolates.

Keywords:
Antibacterial effect / Biofilm inhibition / Herbal extracts / spp. / Synergistic effect
Source:
Journal of Herbal Medicine, 2021, 28, 100445-
Publisher:
  • Elsevier GmbH
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200178 (University of Belgrade, Faculty of Biology) (RS-200178)
  • "Knowledge for progress and stability" (2016–2018)
  • University of Rijeka, Croatia (Grants No. 13.06.2.2.60 and 13.06.1.1.07)
Note:
  • Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4526
Related info:
  • Referenced by
    https://cherry.chem.bg.ac.rs/handle/123456789/4526

DOI: 10.1016/j.hermed.2021.100445

ISSN: 2210-8033

WoS: 000661371200001

Scopus: 2-s2.0-85103723566
[ Google Scholar ]
2
URI
https://www.sciencedirect.com/science/article/pii/S2210803321000257
https://cherry.chem.bg.ac.rs/handle/123456789/4525
Collections
  • Publikacije / Publications
Institution/Community
Hemijski fakultet / Faculty of Chemistry
TY  - JOUR
AU  - Dimkić, Ivica
AU  - Gobin, Ivana
AU  - Begić, Gabrijela
AU  - Repac Antić, Davorka
AU  - Ristivojević, Petar
AU  - Jurica, Karlo
AU  - Berić, Tanja
AU  - Lozo, Jelena
AU  - Abram, Maja
AU  - Stanković, Slaviša
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S2210803321000257
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4525
AB  - Antibacterial and antibiofilm efficacy through a synergistic effect of herbal leaf extracts of bearberry (BE), bearberry tea (BTE), parsley (PE), and the strawberry tree (STE) was evaluated to discover an alternative approach to control urinary tract infections caused by Enterococci. UHPLC–DAD MS/MS analysis indicated that herbal extracts were rich in ellagic and gallic acids, catechin, quercetin, and arbutin, which are strong antioxidants. Mostly, Enterococcus faecalis isolates showed resistance only to gentamicin and/or norfloxacin (26.3 %) and moderate biofilm production (31.5 %), while 12 isolates of Enterococcus faecium showed multiple antibiotic resistance. The minimum inhibitory concentration for the majority of isolates was 1.25 mg ml−1 for STE, but 2.5 mg ml−1 for BE and BTE. Although individual extracts gave higher MIC values, for most isolates, a synergistic effect at lower concentrations was achieved, when BE or BTE (0.625 mg ml−1) was combined with STE (0.31 mg ml−1). The BTE extract was shown to have the strongest individual effect on initial adhesiveness and on biofilm formation to all selected isolates, while the synergism of BTE and STE caused significant biofilm inhibition at all concentrations tested. The synergistic effect achieved of the tested extract combinations might be a starting point in the development of alternative products, effective against antibiotic resistant Enterococcus isolates.
PB  - Elsevier GmbH
T2  - Journal of Herbal Medicine
T2  - Journal of Herbal MedicineJournal of Herbal Medicine
T1  - Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections
VL  - 28
SP  - 100445
DO  - 10.1016/j.hermed.2021.100445
ER  - 
@article{
author = "Dimkić, Ivica and Gobin, Ivana and Begić, Gabrijela and Repac Antić, Davorka and Ristivojević, Petar and Jurica, Karlo and Berić, Tanja and Lozo, Jelena and Abram, Maja and Stanković, Slaviša",
year = "2021",
abstract = "Antibacterial and antibiofilm efficacy through a synergistic effect of herbal leaf extracts of bearberry (BE), bearberry tea (BTE), parsley (PE), and the strawberry tree (STE) was evaluated to discover an alternative approach to control urinary tract infections caused by Enterococci. UHPLC–DAD MS/MS analysis indicated that herbal extracts were rich in ellagic and gallic acids, catechin, quercetin, and arbutin, which are strong antioxidants. Mostly, Enterococcus faecalis isolates showed resistance only to gentamicin and/or norfloxacin (26.3 %) and moderate biofilm production (31.5 %), while 12 isolates of Enterococcus faecium showed multiple antibiotic resistance. The minimum inhibitory concentration for the majority of isolates was 1.25 mg ml−1 for STE, but 2.5 mg ml−1 for BE and BTE. Although individual extracts gave higher MIC values, for most isolates, a synergistic effect at lower concentrations was achieved, when BE or BTE (0.625 mg ml−1) was combined with STE (0.31 mg ml−1). The BTE extract was shown to have the strongest individual effect on initial adhesiveness and on biofilm formation to all selected isolates, while the synergism of BTE and STE caused significant biofilm inhibition at all concentrations tested. The synergistic effect achieved of the tested extract combinations might be a starting point in the development of alternative products, effective against antibiotic resistant Enterococcus isolates.",
publisher = "Elsevier GmbH",
journal = "Journal of Herbal Medicine, Journal of Herbal MedicineJournal of Herbal Medicine",
title = "Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections",
volume = "28",
pages = "100445",
doi = "10.1016/j.hermed.2021.100445"
}
Dimkić, I., Gobin, I., Begić, G., Repac Antić, D., Ristivojević, P., Jurica, K., Berić, T., Lozo, J., Abram, M.,& Stanković, S.. (2021). Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections. in Journal of Herbal Medicine
Elsevier GmbH., 28, 100445.
https://doi.org/10.1016/j.hermed.2021.100445
Dimkić I, Gobin I, Begić G, Repac Antić D, Ristivojević P, Jurica K, Berić T, Lozo J, Abram M, Stanković S. Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections. in Journal of Herbal Medicine. 2021;28:100445.
doi:10.1016/j.hermed.2021.100445 .
Dimkić, Ivica, Gobin, Ivana, Begić, Gabrijela, Repac Antić, Davorka, Ristivojević, Petar, Jurica, Karlo, Berić, Tanja, Lozo, Jelena, Abram, Maja, Stanković, Slaviša, "Antibacterial activity of herbal extracts towards uropathogenic Enterococcus isolates as a natural approach in control of urinary tract infections" in Journal of Herbal Medicine, 28 (2021):100445,
https://doi.org/10.1016/j.hermed.2021.100445 . .

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