Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars
Само за регистроване кориснике
2021
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for the enantioselective carbon–carbon bond formation, often offering more efficient, economical and environmentally friendly synthesis of chiral molecules. On the other hand, reductive amination is one of the most important reactions in synthesis of biologically active compounds and drug candidates. Coupling these two reactions results in a powerful combination that allows for a rapid, stereoselective access to substituted, highly functionalized five- and six-membered N-heterocycles. This minireview illustrates the applicability of this approach as the key feature in syntheses of various iminosugars – a class of polyhydroxylated alkaloids with a range of interesting biological activities and high pharmacological potential.
Кључне речи:
Aldol reaction / Asymmetric synthesis / Iminosugars / Organocatalysis / Reductive aminationИзвор:
European Journal of Organic Chemistry, 2021, 2021, 22, 3241-3250Издавач:
- Wiley
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Serbian Academyof Sciences and Arts, Project No F193.
Напомена:
- Peer-reviewed manuscript: https://cherry.chem.bg.ac.rs/handle/123456789/4577
DOI: 10.1002/ejoc.202100398
ISSN: 1434-193X
WoS: 000664610800012
Scopus: 2-s2.0-85108284643
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202100398https://cherry.chem.bg.ac.rs/handle/123456789/4576
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ferjančić, Zorana AU - Saičić, Radomir PY - 2021 UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202100398 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4576 AB - Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for the enantioselective carbon–carbon bond formation, often offering more efficient, economical and environmentally friendly synthesis of chiral molecules. On the other hand, reductive amination is one of the most important reactions in synthesis of biologically active compounds and drug candidates. Coupling these two reactions results in a powerful combination that allows for a rapid, stereoselective access to substituted, highly functionalized five- and six-membered N-heterocycles. This minireview illustrates the applicability of this approach as the key feature in syntheses of various iminosugars – a class of polyhydroxylated alkaloids with a range of interesting biological activities and high pharmacological potential. PB - Wiley T2 - European Journal of Organic Chemistry T1 - Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars VL - 2021 IS - 22 SP - 3241 EP - 3250 DO - 10.1002/ejoc.202100398 ER -
@article{ author = "Ferjančić, Zorana and Saičić, Radomir", year = "2021", abstract = "Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for the enantioselective carbon–carbon bond formation, often offering more efficient, economical and environmentally friendly synthesis of chiral molecules. On the other hand, reductive amination is one of the most important reactions in synthesis of biologically active compounds and drug candidates. Coupling these two reactions results in a powerful combination that allows for a rapid, stereoselective access to substituted, highly functionalized five- and six-membered N-heterocycles. This minireview illustrates the applicability of this approach as the key feature in syntheses of various iminosugars – a class of polyhydroxylated alkaloids with a range of interesting biological activities and high pharmacological potential.", publisher = "Wiley", journal = "European Journal of Organic Chemistry", title = "Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars", volume = "2021", number = "22", pages = "3241-3250", doi = "10.1002/ejoc.202100398" }
Ferjančić, Z.,& Saičić, R.. (2021). Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars. in European Journal of Organic Chemistry Wiley., 2021(22), 3241-3250. https://doi.org/10.1002/ejoc.202100398
Ferjančić Z, Saičić R. Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars. in European Journal of Organic Chemistry. 2021;2021(22):3241-3250. doi:10.1002/ejoc.202100398 .
Ferjančić, Zorana, Saičić, Radomir, "Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars" in European Journal of Organic Chemistry, 2021, no. 22 (2021):3241-3250, https://doi.org/10.1002/ejoc.202100398 . .