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Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars
dc.creator | Ferjančić, Zorana | |
dc.creator | Saičić, Radomir | |
dc.date.accessioned | 2021-09-15T13:18:39Z | |
dc.date.available | 2022-05-17 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1434-193X | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/4577 | |
dc.description.abstract | Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for the enantioselective carbon–carbon bond formation, often offering more efficient, economical and environmentally friendly synthesis of chiral molecules. On the other hand, reductive amination is one of the most important reactions in synthesis of biologically active compounds and drug candidates. Coupling these two reactions results in a powerful combination that allows for a rapid, stereoselective access to substituted, highly functionalized five- and six-membered N-heterocycles. This minireview illustrates the applicability of this approach as the key feature in syntheses of various iminosugars – a class of polyhydroxylated alkaloids with a range of interesting biological activities and high pharmacological potential. | |
dc.language | en | |
dc.publisher | Wiley | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation | Serbian Academyof Sciences and Arts, Project No F193. | |
dc.relation.isversionof | https://doi.org/10.1002/ejoc.202100398 | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | European Journal of Organic Chemistry | |
dc.subject | Aldol reaction | |
dc.subject | Asymmetric synthesis | |
dc.subject | Iminosugars | |
dc.subject | Organocatalysis | |
dc.subject | Reductive amination | |
dc.title | Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars | |
dc.type | article | en |
dc.rights.license | BY-NC | |
dcterms.abstract | Саичић, Радомир; Ферјанчић, Зорана; | |
dc.citation.volume | 2021 | |
dc.citation.issue | 22 | |
dc.citation.spage | 3241 | |
dc.citation.epage | 3250 | |
dc.identifier.wos | 000664610800012 | |
dc.identifier.doi | 10.1002/ejoc.202100398 | |
dc.citation.rank | M22~ | |
dc.description.other | This is the peer-reviewed version of the article: Ferjancic, Z.; Saicic, R. N. Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars. European Journal of Organic Chemistry 2021, 2021 (22), 3241–3250. [https://doi.org/10.1002/ejoc.202100398]. | |
dc.type.version | acceptedVersion | |
dc.identifier.scopus | 2-s2.0-85108284643 | |
dc.identifier.fulltext | http://cherry.chem.bg.ac.rs/bitstream/id/27617/Combining_Organocatalyzed_Aldolization_acc_2021.pdf |