Metal complexes with α-picolinic acid frameworks and their antitumor activity
Abstract
Pyridine (carboxylate) type of molecules has been intensively studied since early 2000s as it provides diverse design capabilities in terms of coordination to metal ions. Several structural motifs featuring mono-, bi-, and pentadentate binding modes are discussed in a combination with a variety of different substituents with the pyridine unit. In this context, the current review underlines a brief summary of advances on metal complexes with pyridine-based ligands aimed for further development as metallodrug. In line with this, we also highlight their key properties, different synthetic strategies employed in the preparation, and possible structure–property correlations, indicating advantages and limitations of the applied methods used within documented studies.
Keywords:
Arene / Cancer / Carboxylate / Metallodrug / Picolinate / PyridineSource:
Inorganica Chimica Acta, 2021, 527, 120582-Publisher:
- Elsevier
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200288 (Innovation Center of the Faculty of Chemistry) (RS-200288)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
DOI: 10.1016/j.ica.2021.120582
ISSN: 0020-1693
WoS: 000701214800005
Scopus: 2-s2.0-85113676912
URI
https://www.sciencedirect.com/science/article/pii/S0020169321003388https://cherry.chem.bg.ac.rs/handle/123456789/4662
Collections
Institution/Community
Hemijski fakultetTY - JOUR AU - Mihajlović-Lalić, Ljiljana AU - Poljarević, Jelena AU - Grgurić-Šipka, Sanja PY - 2021 UR - https://www.sciencedirect.com/science/article/pii/S0020169321003388 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4662 AB - Pyridine (carboxylate) type of molecules has been intensively studied since early 2000s as it provides diverse design capabilities in terms of coordination to metal ions. Several structural motifs featuring mono-, bi-, and pentadentate binding modes are discussed in a combination with a variety of different substituents with the pyridine unit. In this context, the current review underlines a brief summary of advances on metal complexes with pyridine-based ligands aimed for further development as metallodrug. In line with this, we also highlight their key properties, different synthetic strategies employed in the preparation, and possible structure–property correlations, indicating advantages and limitations of the applied methods used within documented studies. PB - Elsevier T2 - Inorganica Chimica Acta T1 - Metal complexes with α-picolinic acid frameworks and their antitumor activity VL - 527 SP - 120582 DO - 10.1016/j.ica.2021.120582 ER -
@article{ author = "Mihajlović-Lalić, Ljiljana and Poljarević, Jelena and Grgurić-Šipka, Sanja", year = "2021", abstract = "Pyridine (carboxylate) type of molecules has been intensively studied since early 2000s as it provides diverse design capabilities in terms of coordination to metal ions. Several structural motifs featuring mono-, bi-, and pentadentate binding modes are discussed in a combination with a variety of different substituents with the pyridine unit. In this context, the current review underlines a brief summary of advances on metal complexes with pyridine-based ligands aimed for further development as metallodrug. In line with this, we also highlight their key properties, different synthetic strategies employed in the preparation, and possible structure–property correlations, indicating advantages and limitations of the applied methods used within documented studies.", publisher = "Elsevier", journal = "Inorganica Chimica Acta", title = "Metal complexes with α-picolinic acid frameworks and their antitumor activity", volume = "527", pages = "120582", doi = "10.1016/j.ica.2021.120582" }
Mihajlović-Lalić, L., Poljarević, J.,& Grgurić-Šipka, S.. (2021). Metal complexes with α-picolinic acid frameworks and their antitumor activity. in Inorganica Chimica Acta Elsevier., 527, 120582. https://doi.org/10.1016/j.ica.2021.120582
Mihajlović-Lalić L, Poljarević J, Grgurić-Šipka S. Metal complexes with α-picolinic acid frameworks and their antitumor activity. in Inorganica Chimica Acta. 2021;527:120582. doi:10.1016/j.ica.2021.120582 .
Mihajlović-Lalić, Ljiljana, Poljarević, Jelena, Grgurić-Šipka, Sanja, "Metal complexes with α-picolinic acid frameworks and their antitumor activity" in Inorganica Chimica Acta, 527 (2021):120582, https://doi.org/10.1016/j.ica.2021.120582 . .