Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone
Authorized Users Only
Article (Published version)
MetadataShow full item record
Based on biological properties of epoxyquinols from natural sources, bromo and epoxyquinols derived from estrone were synthesized and screened against Fem-X. HeLa and K-562 cell lines. Evidence was found that the bromine atom and the epoxy moiety significantly increase the antiproliferative activity within the series. (C) 2001 Elsevier Science Ltd. All rights reserved.
Source:Bioorganic and Medicinal Chemistry Letters, 2001, 11, 16, 2197-2200
- Pergamon-Elsevier Science Ltd, Oxford