Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level
Samo za registrovane korisnike
2022
Autori
Jagodić, JovanaRovčanin, Branislav
Paunović, Ivan
Mihailović, Mladen
Zečević, Nebojša
Manojlović, Dragan D.
Stojsavljević, Aleksandar
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Pheochromocytoma (PCC) is an unusual benign adrenal tumor with an unexamined status of the elements. This study delivers the first insight into the levels of microelements (Mn, Co, Cu, Zn, As, Se, Th), toxic elements (Cd, Pb, U), and macroelements (Na, K, Mg, Ca) in both adrenal tissue and whole blood samples collected from PCC patients. The results were strengthened by comparing recorded findings with the patients’ healthy adrenal tissue (HAT) and with whole blood samples from the healthy individuals. PCCs had significantly higher levels of Zn, Se, Na, K, and Mg and lower levels of Mn, Co, Pb, and As than that of HATs. Compared to healthy blood samples, the patients’ blood exhibited considerably higher levels of Na, K, and Ca but significantly lower levels of Mn, Cu, Zn, Se, and Mg. Females had significantly higher levels of essential Se and toxic Pb and Cd in their PCC tissue samples compared to males. PCC tissue levels of Mn and Cu were significantly elevated in smokers over levels ...in nonsmokers and in PCC patients with tumor sizes below 5 cm compared to PCC diameters above 5 cm. The data presented in this study provide a new insight into the pathophysiology of PCC. Thus, recorded elements should be considered as initiators/modifiers of PCC and potential inductors of malignant transformation. The findings of this research deepen scientific understanding of this rare adrenal disease, which, in turn, could highlight the pathogenesis of PCC.
Ključne reči:
Pheochromocytoma (PCC) / Microelements/trace elements / Macroelements / Adrenal tissue / Whole bloodIzvor:
Biological Trace Element Research, 2022, 200, 8, 3482-3490Izdavač:
- Springer
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (RS-MESTD-inst-2020-200288)
DOI: 10.1007/s12011-021-02945-2
ISSN: 0163-4984
WoS: 000705763600002
Scopus: 2-s2.0-85116450145
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jagodić, Jovana AU - Rovčanin, Branislav AU - Paunović, Ivan AU - Mihailović, Mladen AU - Zečević, Nebojša AU - Manojlović, Dragan D. AU - Stojsavljević, Aleksandar PY - 2022 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4737 AB - Pheochromocytoma (PCC) is an unusual benign adrenal tumor with an unexamined status of the elements. This study delivers the first insight into the levels of microelements (Mn, Co, Cu, Zn, As, Se, Th), toxic elements (Cd, Pb, U), and macroelements (Na, K, Mg, Ca) in both adrenal tissue and whole blood samples collected from PCC patients. The results were strengthened by comparing recorded findings with the patients’ healthy adrenal tissue (HAT) and with whole blood samples from the healthy individuals. PCCs had significantly higher levels of Zn, Se, Na, K, and Mg and lower levels of Mn, Co, Pb, and As than that of HATs. Compared to healthy blood samples, the patients’ blood exhibited considerably higher levels of Na, K, and Ca but significantly lower levels of Mn, Cu, Zn, Se, and Mg. Females had significantly higher levels of essential Se and toxic Pb and Cd in their PCC tissue samples compared to males. PCC tissue levels of Mn and Cu were significantly elevated in smokers over levels in nonsmokers and in PCC patients with tumor sizes below 5 cm compared to PCC diameters above 5 cm. The data presented in this study provide a new insight into the pathophysiology of PCC. Thus, recorded elements should be considered as initiators/modifiers of PCC and potential inductors of malignant transformation. The findings of this research deepen scientific understanding of this rare adrenal disease, which, in turn, could highlight the pathogenesis of PCC. PB - Springer T2 - Biological Trace Element Research T1 - Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level VL - 200 IS - 8 SP - 3482 EP - 3490 DO - 10.1007/s12011-021-02945-2 ER -
@article{ author = "Jagodić, Jovana and Rovčanin, Branislav and Paunović, Ivan and Mihailović, Mladen and Zečević, Nebojša and Manojlović, Dragan D. and Stojsavljević, Aleksandar", year = "2022", abstract = "Pheochromocytoma (PCC) is an unusual benign adrenal tumor with an unexamined status of the elements. This study delivers the first insight into the levels of microelements (Mn, Co, Cu, Zn, As, Se, Th), toxic elements (Cd, Pb, U), and macroelements (Na, K, Mg, Ca) in both adrenal tissue and whole blood samples collected from PCC patients. The results were strengthened by comparing recorded findings with the patients’ healthy adrenal tissue (HAT) and with whole blood samples from the healthy individuals. PCCs had significantly higher levels of Zn, Se, Na, K, and Mg and lower levels of Mn, Co, Pb, and As than that of HATs. Compared to healthy blood samples, the patients’ blood exhibited considerably higher levels of Na, K, and Ca but significantly lower levels of Mn, Cu, Zn, Se, and Mg. Females had significantly higher levels of essential Se and toxic Pb and Cd in their PCC tissue samples compared to males. PCC tissue levels of Mn and Cu were significantly elevated in smokers over levels in nonsmokers and in PCC patients with tumor sizes below 5 cm compared to PCC diameters above 5 cm. The data presented in this study provide a new insight into the pathophysiology of PCC. Thus, recorded elements should be considered as initiators/modifiers of PCC and potential inductors of malignant transformation. The findings of this research deepen scientific understanding of this rare adrenal disease, which, in turn, could highlight the pathogenesis of PCC.", publisher = "Springer", journal = "Biological Trace Element Research", title = "Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level", volume = "200", number = "8", pages = "3482-3490", doi = "10.1007/s12011-021-02945-2" }
Jagodić, J., Rovčanin, B., Paunović, I., Mihailović, M., Zečević, N., Manojlović, D. D.,& Stojsavljević, A.. (2022). Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level. in Biological Trace Element Research Springer., 200(8), 3482-3490. https://doi.org/10.1007/s12011-021-02945-2
Jagodić J, Rovčanin B, Paunović I, Mihailović M, Zečević N, Manojlović DD, Stojsavljević A. Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level. in Biological Trace Element Research. 2022;200(8):3482-3490. doi:10.1007/s12011-021-02945-2 .
Jagodić, Jovana, Rovčanin, Branislav, Paunović, Ivan, Mihailović, Mladen, Zečević, Nebojša, Manojlović, Dragan D., Stojsavljević, Aleksandar, "Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level" in Biological Trace Element Research, 200, no. 8 (2022):3482-3490, https://doi.org/10.1007/s12011-021-02945-2 . .