Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer
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2021
Authors
Stojsavljević, Aleksandar
Rovčanin, Branislav

Jagodić, Jovana

Krstić, Đurđa D.

Paunović, Ivan
Gavrović-Jankulović, Marija

Manojlović, Dragan D.

Article (Published version)

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Modest progress has been made in understanding the role of trace elements as endocrine disruptors. The aim of this study was to examine whether there is a change in the content of trace elements in thyroid disease, as well as whether the ratio of elements could be considered a blood marker for thyroid disease. In addition, this study examined the influence of biological and clinical/pathological parameters on the elemental profile. Blood samples from patients diagnosed with multinodular goiter (MNG), thyroid adenoma (TA), and thyroid cancer (TC) were examined and compared with control samples using chemometric analysis. The concentrations of essential (Mn, Co, Cu, Zn, Se) and toxic elements (Ni, As, Cd, Pb, U) were determined by ICP-MS. This study showed for the first time that the content of Mn, Co, Ni, Cu, Zn, Se, and Pb in pathological blood samples was significantly lower compared to the control, while opposite results were obtained for As, Cd, and U. Based on the classification mo...del, the most important trace metals for discrimination of MNG and TC from the control group (CG) were Co and Zn, while Co, Zn, and Mn influenced the distinction of CG from TA. Moreover, it was found that Cu/Zn and U/Se ratios had significantly increased values in pathological blood samples leading to the possibility of establishing new circulating screening markers. These findings can represent significant translational information since these diseases are widespread and the diagnostic procedure is still difficult in many cases.
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Biological Trace Element Research, 2021, 199, 11, 4055-4065Publisher:
- Springer
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DOI: 10.1007/s12011-020-02542-9
ISSN: 0163-4984
WoS: 000605536800003
Scopus: 2-s2.0-85099058366
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stojsavljević, Aleksandar AU - Rovčanin, Branislav AU - Jagodić, Jovana AU - Krstić, Đurđa D. AU - Paunović, Ivan AU - Gavrović-Jankulović, Marija AU - Manojlović, Dragan D. PY - 2021 UR - https://doi.org/10.1007/s12011-020-02542-9 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4780 AB - Modest progress has been made in understanding the role of trace elements as endocrine disruptors. The aim of this study was to examine whether there is a change in the content of trace elements in thyroid disease, as well as whether the ratio of elements could be considered a blood marker for thyroid disease. In addition, this study examined the influence of biological and clinical/pathological parameters on the elemental profile. Blood samples from patients diagnosed with multinodular goiter (MNG), thyroid adenoma (TA), and thyroid cancer (TC) were examined and compared with control samples using chemometric analysis. The concentrations of essential (Mn, Co, Cu, Zn, Se) and toxic elements (Ni, As, Cd, Pb, U) were determined by ICP-MS. This study showed for the first time that the content of Mn, Co, Ni, Cu, Zn, Se, and Pb in pathological blood samples was significantly lower compared to the control, while opposite results were obtained for As, Cd, and U. Based on the classification model, the most important trace metals for discrimination of MNG and TC from the control group (CG) were Co and Zn, while Co, Zn, and Mn influenced the distinction of CG from TA. Moreover, it was found that Cu/Zn and U/Se ratios had significantly increased values in pathological blood samples leading to the possibility of establishing new circulating screening markers. These findings can represent significant translational information since these diseases are widespread and the diagnostic procedure is still difficult in many cases. PB - Springer T2 - Biological Trace Element Research T1 - Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer VL - 199 IS - 11 SP - 4055 EP - 4065 DO - 10.1007/s12011-020-02542-9 ER -
@article{ author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Jagodić, Jovana and Krstić, Đurđa D. and Paunović, Ivan and Gavrović-Jankulović, Marija and Manojlović, Dragan D.", year = "2021", abstract = "Modest progress has been made in understanding the role of trace elements as endocrine disruptors. The aim of this study was to examine whether there is a change in the content of trace elements in thyroid disease, as well as whether the ratio of elements could be considered a blood marker for thyroid disease. In addition, this study examined the influence of biological and clinical/pathological parameters on the elemental profile. Blood samples from patients diagnosed with multinodular goiter (MNG), thyroid adenoma (TA), and thyroid cancer (TC) were examined and compared with control samples using chemometric analysis. The concentrations of essential (Mn, Co, Cu, Zn, Se) and toxic elements (Ni, As, Cd, Pb, U) were determined by ICP-MS. This study showed for the first time that the content of Mn, Co, Ni, Cu, Zn, Se, and Pb in pathological blood samples was significantly lower compared to the control, while opposite results were obtained for As, Cd, and U. Based on the classification model, the most important trace metals for discrimination of MNG and TC from the control group (CG) were Co and Zn, while Co, Zn, and Mn influenced the distinction of CG from TA. Moreover, it was found that Cu/Zn and U/Se ratios had significantly increased values in pathological blood samples leading to the possibility of establishing new circulating screening markers. These findings can represent significant translational information since these diseases are widespread and the diagnostic procedure is still difficult in many cases.", publisher = "Springer", journal = "Biological Trace Element Research", title = "Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer", volume = "199", number = "11", pages = "4055-4065", doi = "10.1007/s12011-020-02542-9" }
Stojsavljević, A., Rovčanin, B., Jagodić, J., Krstić, Đ. D., Paunović, I., Gavrović-Jankulović, M.,& Manojlović, D. D.. (2021). Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer. in Biological Trace Element Research Springer., 199(11), 4055-4065. https://doi.org/10.1007/s12011-020-02542-9
Stojsavljević A, Rovčanin B, Jagodić J, Krstić ĐD, Paunović I, Gavrović-Jankulović M, Manojlović DD. Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer. in Biological Trace Element Research. 2021;199(11):4055-4065. doi:10.1007/s12011-020-02542-9 .
Stojsavljević, Aleksandar, Rovčanin, Branislav, Jagodić, Jovana, Krstić, Đurđa D., Paunović, Ivan, Gavrović-Jankulović, Marija, Manojlović, Dragan D., "Alteration of Trace Elements in Multinodular Goiter, Thyroid Adenoma, and Thyroid Cancer" in Biological Trace Element Research, 199, no. 11 (2021):4055-4065, https://doi.org/10.1007/s12011-020-02542-9 . .