Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention
Authors
Gligorijevic, NikolaRadomirović, Mirjana Ž.

Nedić, Olgica

Stojadinović, Marija M.

Khulal, Urmila
Stanić-Vučinić, Dragana

Ćirković-Veličković, Tanja

Article (Published version)
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The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-base...d natural approaches for preventing and treating COVID-19.
Keywords:
antiviral effects / antiviral targets / polyphenols / SARS-CoV-2Source:
International Journal of Molecular Sciences, 2021, 22, 22, 12385-Publisher:
- MDPI
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Serbian Academy of Sciences and Arts, grant number F-26.
- FoodEnTwin-Twinning of research activities for the frontier research in the fields of food, nutrition and environmental omics (EU-810752)
DOI: 10.3390/ijms222212385
ISSN: 1422-0067
WoS: 000724589300001
Scopus: 2-s2.0-85119049091
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Hemijski fakultetTY - JOUR AU - Gligorijevic, Nikola AU - Radomirović, Mirjana Ž. AU - Nedić, Olgica AU - Stojadinović, Marija M. AU - Khulal, Urmila AU - Stanić-Vučinić, Dragana AU - Ćirković-Veličković, Tanja PY - 2021 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4784 AB - The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19. PB - MDPI T2 - International Journal of Molecular Sciences T1 - Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention VL - 22 IS - 22 SP - 12385 DO - 10.3390/ijms222212385 ER -
@article{ author = "Gligorijevic, Nikola and Radomirović, Mirjana Ž. and Nedić, Olgica and Stojadinović, Marija M. and Khulal, Urmila and Stanić-Vučinić, Dragana and Ćirković-Veličković, Tanja", year = "2021", abstract = "The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention", volume = "22", number = "22", pages = "12385", doi = "10.3390/ijms222212385" }
Gligorijevic, N., Radomirović, M. Ž., Nedić, O., Stojadinović, M. M., Khulal, U., Stanić-Vučinić, D.,& Ćirković-Veličković, T.. (2021). Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention. in International Journal of Molecular Sciences MDPI., 22(22), 12385. https://doi.org/10.3390/ijms222212385
Gligorijevic N, Radomirović MŽ, Nedić O, Stojadinović MM, Khulal U, Stanić-Vučinić D, Ćirković-Veličković T. Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention. in International Journal of Molecular Sciences. 2021;22(22):12385. doi:10.3390/ijms222212385 .
Gligorijevic, Nikola, Radomirović, Mirjana Ž., Nedić, Olgica, Stojadinović, Marija M., Khulal, Urmila, Stanić-Vučinić, Dragana, Ćirković-Veličković, Tanja, "Molecular Mechanisms of Possible Action of Phenolic Compounds in COVID-19 Protection and Prevention" in International Journal of Molecular Sciences, 22, no. 22 (2021):12385, https://doi.org/10.3390/ijms222212385 . .