Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones
Authors
Čobeljić, BožidarŽivković, Marijana B.
Matić, Ivana Z.
Novaković, Irena T.
Sladić, Dušan
Anđelković, Katarina K.
Krstić, Natalija M.
Article (Published version)
Metadata
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In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.
Keywords:
3-oxo-α / β-unsaturated steroids / hydrazones / square-planar complexes / cytotoxicity / antimicrobial activitySource:
Journal of the Serbian Chemical Society, 2021, 86, 5, 459-468Publisher:
- Serbian Chemical Society
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-MESTD-inst-2020-200026)
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Čobeljić, Božidar AU - Živković, Marijana B. AU - Matić, Ivana Z. AU - Novaković, Irena T. AU - Sladić, Dušan AU - Anđelković, Katarina K. AU - Krstić, Natalija M. PY - 2021 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4788 AB - In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones VL - 86 IS - 5 SP - 459 EP - 468 UR - https://hdl.handle.net/21.15107/rcub_cherry_4788 ER -
@article{ author = "Čobeljić, Božidar and Živković, Marijana B. and Matić, Ivana Z. and Novaković, Irena T. and Sladić, Dušan and Anđelković, Katarina K. and Krstić, Natalija M.", year = "2021", abstract = "In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones", volume = "86", number = "5", pages = "459-468", url = "https://hdl.handle.net/21.15107/rcub_cherry_4788" }
Čobeljić, B., Živković, M. B., Matić, I. Z., Novaković, I. T., Sladić, D., Anđelković, K. K.,& Krstić, N. M.. (2021). Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones. in Journal of the Serbian Chemical Society Serbian Chemical Society., 86(5), 459-468. https://hdl.handle.net/21.15107/rcub_cherry_4788
Čobeljić B, Živković MB, Matić IZ, Novaković IT, Sladić D, Anđelković KK, Krstić NM. Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones. in Journal of the Serbian Chemical Society. 2021;86(5):459-468. https://hdl.handle.net/21.15107/rcub_cherry_4788 .
Čobeljić, Božidar, Živković, Marijana B., Matić, Ivana Z., Novaković, Irena T., Sladić, Dušan, Anđelković, Katarina K., Krstić, Natalija M., "Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones" in Journal of the Serbian Chemical Society, 86, no. 5 (2021):459-468, https://hdl.handle.net/21.15107/rcub_cherry_4788 .