Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia
Authorized Users Only
2021
Authors
Kojadinović, Milica I.Glibetić, Marija D.
Vučić, Vesna M.
Popović, Milica M.
Vidović, Nevena Đ.
Debeljak-Martačić, Jasmina D.
Arsić, Aleksandra Č.
Article (Published version)
Metadata
Show full item recordAbstract
Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the lev...els of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia.
Keywords:
fatty acids / phospholipids / polyphenols / pomegranate juiceSource:
Journal of Medicinal Food, 2021, 24, 9Publisher:
- Mary Ann Liebert, Inc, New Rochelle
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-MESTD-inst-2020-200015)
DOI: 10.1089/jmf.2020.0122
ISSN: 1096-620X
PubMed: 33523763
WoS: 000614550300001
Scopus: 2-s2.0-85103043991
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Kojadinović, Milica I. AU - Glibetić, Marija D. AU - Vučić, Vesna M. AU - Popović, Milica M. AU - Vidović, Nevena Đ. AU - Debeljak-Martačić, Jasmina D. AU - Arsić, Aleksandra Č. PY - 2021 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4791 AB - Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the levels of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia. PB - Mary Ann Liebert, Inc, New Rochelle T2 - Journal of Medicinal Food T1 - Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia VL - 24 IS - 9 DO - 10.1089/jmf.2020.0122 ER -
@article{ author = "Kojadinović, Milica I. and Glibetić, Marija D. and Vučić, Vesna M. and Popović, Milica M. and Vidović, Nevena Đ. and Debeljak-Martačić, Jasmina D. and Arsić, Aleksandra Č.", year = "2021", abstract = "Pomegranate juice (PJ) has potential positive effects in patients with metabolic disturbances due to a high content of polyphenols. The objective of this study was to evaluate effects of a 2-week consumption of dietary doses of PJ on blood pressure, lipid metabolism, and oxidative stress markers in overweight patients with dyslipidemia. Twenty-four patients, 8 males and 16 females, 40-60 years of age, with established overweight and dyslipidemia were randomly assigned into intervention group, who consumed 300 mL of PJ daily for 2 weeks, or control group. After 2 weeks of juice intake, intervention group had significantly lower diastolic blood pressure, low-density lipoprotein cholesterol, aminotransferase, and activity of glutathione peroxidase. Furthermore, patients who consumed PJ had reduced percentage of docosahexaenoic acid (22:6n-3, DHA) in plasma phospholipids and increased estimated activity of stearoyl-CoA desaturase. In erythrocytes, we found a significant increase in the levels of dihomo-gamma- linolenic acid (20:3n-6, DGLA) and DHA, as well as in estimated activity of Delta 6 desaturase, and a decrease in estimated activity of Delta 5 desaturase. These results show that even a short-term consumption of dietary doses of PJ exerts beneficial effects and affects lipid metabolism in overweight patients with dyslipidemia.", publisher = "Mary Ann Liebert, Inc, New Rochelle", journal = "Journal of Medicinal Food", title = "Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia", volume = "24", number = "9", doi = "10.1089/jmf.2020.0122" }
Kojadinović, M. I., Glibetić, M. D., Vučić, V. M., Popović, M. M., Vidović, N. Đ., Debeljak-Martačić, J. D.,& Arsić, A. Č.. (2021). Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia. in Journal of Medicinal Food Mary Ann Liebert, Inc, New Rochelle., 24(9). https://doi.org/10.1089/jmf.2020.0122
Kojadinović MI, Glibetić MD, Vučić VM, Popović MM, Vidović NĐ, Debeljak-Martačić JD, Arsić AČ. Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia. in Journal of Medicinal Food. 2021;24(9). doi:10.1089/jmf.2020.0122 .
Kojadinović, Milica I., Glibetić, Marija D., Vučić, Vesna M., Popović, Milica M., Vidović, Nevena Đ., Debeljak-Martačić, Jasmina D., Arsić, Aleksandra Č., "Short-Term Consumption of Pomegranate Juice Alleviates Some Metabolic Disturbances in Overweight Patients with Dyslipidemia" in Journal of Medicinal Food, 24, no. 9 (2021), https://doi.org/10.1089/jmf.2020.0122 . .