Enterocytes in Food Hypersensitivity Reactions
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Food hypersensitivity reactions are adverse reactions to harmless dietary substances, whose causes are hidden within derangements of the complex immune machinery of humans and mammals. Until recently, enterocytes were considered as solely absorptive cells providing a physical barrier for unwanted lumen constituents. This review focuses on the enterocytes, which are the hub for innate and adaptive immune reactions. Furthermore, the ambiguous nature of enterocytes is also reflected in the fact that enterocytes can be considered as antigen-presenting cells since they constitutively express major histocompatibility complex (MHC) class II molecules. Taken together, it becomes clear that enterocytes have an immense role in maintaining oral tolerance to foreign antigens. In general, the immune system and its mechanisms underlying food hypersensitivity are still unknown and the involvement of components belonging to other anatomical systems, such as enterocytes, in these mechanisms make their ...elucidation even more difficult. The findings from studies with animal models provide us with valuable information about allergic mechanisms in the animal world, while on the other hand, these models are used to extrapolate results to the pathological conditions occurring in humans. There is a constant need for studies that deal with this topic and can overcome the glitches related to ethics in working with animals.
Ključne reči:
animal models of food allergy / antigens / CD23 / enterocytes / food allergy / food hypersensitivity / oral toleranceIzvor:
Animals, 2021, 11, 9, 2713-Izdavač:
- MDPI
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200168 (Univerzitet u Beogradu, Hemijski fakultet) (RS-MESTD-inst-2020-200168)
- FoodEnTwin-Twinning of research activities for the frontier research in the fields of food, nutrition and environmental omics (EU-H2020-810752)
- Serbian Academy of Sciences and Arts (No. F-26)
DOI: 10.3390/ani11092713
ISSN: 2076-2615
PubMed: 34573679
WoS: 000699070700001
Scopus: 2-s2.0-85114987135
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Krstić-Ristivojević, Maja AU - Apostolović, Danijela AU - Smiljanić, Katarina PY - 2021 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4809 AB - Food hypersensitivity reactions are adverse reactions to harmless dietary substances, whose causes are hidden within derangements of the complex immune machinery of humans and mammals. Until recently, enterocytes were considered as solely absorptive cells providing a physical barrier for unwanted lumen constituents. This review focuses on the enterocytes, which are the hub for innate and adaptive immune reactions. Furthermore, the ambiguous nature of enterocytes is also reflected in the fact that enterocytes can be considered as antigen-presenting cells since they constitutively express major histocompatibility complex (MHC) class II molecules. Taken together, it becomes clear that enterocytes have an immense role in maintaining oral tolerance to foreign antigens. In general, the immune system and its mechanisms underlying food hypersensitivity are still unknown and the involvement of components belonging to other anatomical systems, such as enterocytes, in these mechanisms make their elucidation even more difficult. The findings from studies with animal models provide us with valuable information about allergic mechanisms in the animal world, while on the other hand, these models are used to extrapolate results to the pathological conditions occurring in humans. There is a constant need for studies that deal with this topic and can overcome the glitches related to ethics in working with animals. PB - MDPI T2 - Animals T1 - Enterocytes in Food Hypersensitivity Reactions VL - 11 IS - 9 SP - 2713 DO - 10.3390/ani11092713 ER -
@article{ author = "Krstić-Ristivojević, Maja and Apostolović, Danijela and Smiljanić, Katarina", year = "2021", abstract = "Food hypersensitivity reactions are adverse reactions to harmless dietary substances, whose causes are hidden within derangements of the complex immune machinery of humans and mammals. Until recently, enterocytes were considered as solely absorptive cells providing a physical barrier for unwanted lumen constituents. This review focuses on the enterocytes, which are the hub for innate and adaptive immune reactions. Furthermore, the ambiguous nature of enterocytes is also reflected in the fact that enterocytes can be considered as antigen-presenting cells since they constitutively express major histocompatibility complex (MHC) class II molecules. Taken together, it becomes clear that enterocytes have an immense role in maintaining oral tolerance to foreign antigens. In general, the immune system and its mechanisms underlying food hypersensitivity are still unknown and the involvement of components belonging to other anatomical systems, such as enterocytes, in these mechanisms make their elucidation even more difficult. The findings from studies with animal models provide us with valuable information about allergic mechanisms in the animal world, while on the other hand, these models are used to extrapolate results to the pathological conditions occurring in humans. There is a constant need for studies that deal with this topic and can overcome the glitches related to ethics in working with animals.", publisher = "MDPI", journal = "Animals", title = "Enterocytes in Food Hypersensitivity Reactions", volume = "11", number = "9", pages = "2713", doi = "10.3390/ani11092713" }
Krstić-Ristivojević, M., Apostolović, D.,& Smiljanić, K.. (2021). Enterocytes in Food Hypersensitivity Reactions. in Animals MDPI., 11(9), 2713. https://doi.org/10.3390/ani11092713
Krstić-Ristivojević M, Apostolović D, Smiljanić K. Enterocytes in Food Hypersensitivity Reactions. in Animals. 2021;11(9):2713. doi:10.3390/ani11092713 .
Krstić-Ristivojević, Maja, Apostolović, Danijela, Smiljanić, Katarina, "Enterocytes in Food Hypersensitivity Reactions" in Animals, 11, no. 9 (2021):2713, https://doi.org/10.3390/ani11092713 . .