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DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina
dc.creator | Sofrenić, Ivana V. | |
dc.creator | Anđelković, Boban D. | |
dc.creator | Vujisić, Ljubodrag V. | |
dc.creator | Novaković, Miroslav M. | |
dc.creator | Knežević, Aleksandar | |
dc.creator | Stanković, Miroslava | |
dc.creator | Milosavljević, Slobodan M. | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2021-12-15T08:16:02Z | |
dc.date.available | 2021-12-15T08:16:02Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | http://cherry.chem.bg.ac.rs/handle/123456789/4819 | |
dc.description.abstract | Eleven 31-methylenlanostane triterpenoids, i.e., seven 21- and four 26-oic acids, as well as a lupane triterpenoid betulin, isolated from the fruiting bodies of the mushroom Fomitopsis betulina, were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. Most of the tested compounds showed a beneficial effect by reducing DNA damage of human lymphocytes more effectively than amifostine, a radioprotective agent, used as a positive control. All the tested compounds decreased MN frequency in the concentration dependent manner, with the concentration of 2.0 µg mL-1 being the most effective – with increase of the concentration the activity slightly decreases. The structure–activity relationship (SAR) studies indicated that the lanostanes containing a conjugated 7,9 (11)-diene system exhibit lower activity than Δ8-analogues. It was also demonstrated that the DNA protective activities within the Δ8-lanostane-26-oic acid group are affected by the substitution in position 3 pattern. In the Δ8 series the oxygenation at C-12 or 16 as well as 21- or 26-oic acid functionality proved beneficial for in vitro protective effect on chromosomal aberrations. Betulin exhibited the lowest protective activity, but it is still comparable to that of amifostine. | |
dc.language.iso | en | |
dc.publisher | Serbian Chemical Society | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | CBMN assey | |
dc.subject | Fomitopsis betulina | |
dc.subject | Lanostane triterpenoid derivatives | |
dc.subject | Micronucleus | |
dc.title | DNA protective activity of triterpenoids isolated from medicinal mushroom Fomitopsis betulina | |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.volume | 86 | |
dc.citation.issue | 9 | |
dc.citation.spage | 809 | |
dc.citation.epage | 817 | |
dc.identifier.wos | 000692558700003 | |
dc.identifier.doi | 10.2298/JSC210401039S | |
dc.citation.rank | M23~ | |
dc.type.version | publishedVersion | sr |
dc.identifier.scopus | 2-s2.0-85114610458 | |
dc.identifier.fulltext | http://cherry.chem.bg.ac.rs/bitstream/id/28691/DNA_protective_activity_pub_2021.pdf |