Show simple item record

dc.creatorStanić-Vučinić, Dragana
dc.creatorStojadinović, Marija M.
dc.creatorRadomirović, Mirjana Ž.
dc.creatorSimović, Ana
dc.creatorRadibratović, Milica
dc.creatorĆirković-Veličković, Tanja
dc.date.accessioned2022-02-18T13:57:34Z
dc.date.available2022-01-08
dc.date.issued2022
dc.identifier.issn1573-4110
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/4884
dc.description.abstractBackground: The world’s production of whey is estimated to be more than 200 milliontons per year. Although whey is an important source of proteins with high nutritional value andbiotechnological importance, it is still considered as a by-product of the dairy industry with loweconomic value due to low industrial exploitation. There are several challenges in the separation ofwhey proteins: low concentration, the complexity of the material and similar properties (pI, molecularmass) of some proteins.Methods: A narrative review of all the relevant papers on the present methodologies based on ionexchange and adsorption principles for isolation of whey proteins, known to the authors, was conductedResults: Traditional ion exchange techniques are widely used for the separation and purification ofthe bovine whey proteins. These methodologies, based on the anion or cation chromatographicprocedures, as well as the combination of aforementioned techniques are still preferential methodsfor the isolation of the whey proteins on the laboratory scale. However, more recent research on ionexchange membranes for this purpose has been introduced, with promising potential to be appliedon the pilot industrial scale. Newly developed methodologies based either on the ion exchangeseparation (for example: simulated moving bed chromatography, expanded bed adsorption, magneticion exchangers, etc.) or adsorption (for example: adsorption on hydroxyapatite or activatedcarbon, or molecular imprinting) are promising approaches for scaling up of the whey proteins’purification processes.Conclusion: Many procedures based on ion exchange are successfully implemented for the separationand purification of whey proteins, providing protein preparations of moderate-to-high yieldand satisfactory purity. However, the authors anticipate further development of adsorption-basedmethodologies for the separation of whey proteins by targeting the differences in proteins’ structuresrather than targeting the differences in molecular masses and pI. The complex composite multilayeredmatrices, including also inorganic components, are promising materials for simultaneousexploiting of the differences in the masses, pI and structures of whey proteins for the separation.
dc.languageen
dc.publisherBentham Science
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172024/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/810752/EU//
dc.relation.isversionofhttps://cherry.chem.bg.ac.rs/handle/123456789/4883
dc.relation.isversionof10.2174/1573411017666210108092338
dc.rightsembargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceCurrent Analytical Chemistry
dc.titleApplication of Ion Exchange and Adsorption Techniques for Separation of Whey Proteins from Bovine Milk
dc.typearticleen
dc.rights.licenseBY-NC-ND
dc.citation.volume18
dc.citation.issue3
dc.citation.spage341
dc.citation.epage359
dc.identifier.wos000754265800006
dc.identifier.doi10.2174/1573411017666210108092338
dc.description.otherThis is the peer-reviewed version of the following article: (1) Radosavljević, J.; Stanić-Vučinić, D.; Stojadinović, M.; Radomirović, M.; Simović, A.; Radibratović, M.; Veličković, T. Ć. Application of Ion Exchange and Adsorption Techniques for Separation of Whey Proteins from Bovine Milk. Current Analytical Chemistry 18 (3), 341–359. [https://doi.org/10.2174/1573411017666210108092338].
dc.type.versionacceptedVersion
dc.identifier.scopus2-s2.0-85123833760
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/28931/Application_of_Ion_acc_2021.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_cherry_4884


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record