An efficient semisynthesis of 7-deoxypaclitaxel from taxine
Само за регистроване кориснике
2001
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield. © The Royal Society of Chemistry 2000.
Извор:
Journal of the Chemical Society, Perkin Transactions 1, 2001, 1, 59-65Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Saičić, Radomir AU - Matović, Radomir PY - 2001 UR - https://cherry.chem.bg.ac.rs/handle/123456789/49 AB - A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield. © The Royal Society of Chemistry 2000. T2 - Journal of the Chemical Society, Perkin Transactions 1 T1 - An efficient semisynthesis of 7-deoxypaclitaxel from taxine IS - 1 SP - 59 EP - 65 UR - https://hdl.handle.net/21.15107/rcub_cherry_49 ER -
@article{ author = "Saičić, Radomir and Matović, Radomir", year = "2001", abstract = "A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 - the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 - a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield. © The Royal Society of Chemistry 2000.", journal = "Journal of the Chemical Society, Perkin Transactions 1", title = "An efficient semisynthesis of 7-deoxypaclitaxel from taxine", number = "1", pages = "59-65", url = "https://hdl.handle.net/21.15107/rcub_cherry_49" }
Saičić, R.,& Matović, R.. (2001). An efficient semisynthesis of 7-deoxypaclitaxel from taxine. in Journal of the Chemical Society, Perkin Transactions 1(1), 59-65. https://hdl.handle.net/21.15107/rcub_cherry_49
Saičić R, Matović R. An efficient semisynthesis of 7-deoxypaclitaxel from taxine. in Journal of the Chemical Society, Perkin Transactions 1. 2001;(1):59-65. https://hdl.handle.net/21.15107/rcub_cherry_49 .
Saičić, Radomir, Matović, Radomir, "An efficient semisynthesis of 7-deoxypaclitaxel from taxine" in Journal of the Chemical Society, Perkin Transactions 1, no. 1 (2001):59-65, https://hdl.handle.net/21.15107/rcub_cherry_49 .