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Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines

Authorized Users Only
2021
Authors
Nikodijević, Danijela D.
Milutinović, Milena G.
Cvetković, Danijela M.
Ćupurdija, Maja Đ.
Jovanović, Milena M.
Mrkić, Ivan V.
Gavrović-Jankulović, Marija
Marković, Snežana D.
Article (Published version)
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Abstract
This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.
Keywords:
Animal products / apoptosis / cell death / honeybee / venom
Source:
Toxin Reviews, 2021, 40, 4, 1272-1279
Publisher:
  • Taylor & Francis
Funding / projects:
  • Preclinical investigation of bioactive substances (RS-41010)
  • Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)
Note:
  • Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4975
Related info:
  • Referenced by
    https://cherry.chem.bg.ac.rs/handle/123456789/4975

DOI: 10.1080/15569543.2019.1680564

ISSN: 1556-9543

WoS: 000492116600001

Scopus: 2-s2.0-85074475935
[ Google Scholar ]
2
3
URI
http://cherry.chem.bg.ac.rs/handle/123456789/4974
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Nikodijević, Danijela D.
AU  - Milutinović, Milena G.
AU  - Cvetković, Danijela M.
AU  - Ćupurdija, Maja Đ.
AU  - Jovanović, Milena M.
AU  - Mrkić, Ivan V.
AU  - Gavrović-Jankulović, Marija
AU  - Marković, Snežana D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4974
AB  - This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.
PB  - Taylor & Francis
T2  - Toxin Reviews
T1  - Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines
VL  - 40
IS  - 4
SP  - 1272
EP  - 1279
DO  - 10.1080/15569543.2019.1680564
ER  - 
@article{
author = "Nikodijević, Danijela D. and Milutinović, Milena G. and Cvetković, Danijela M. and Ćupurdija, Maja Đ. and Jovanović, Milena M. and Mrkić, Ivan V. and Gavrović-Jankulović, Marija and Marković, Snežana D.",
year = "2021",
abstract = "This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.",
publisher = "Taylor & Francis",
journal = "Toxin Reviews",
title = "Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines",
volume = "40",
number = "4",
pages = "1272-1279",
doi = "10.1080/15569543.2019.1680564"
}
Nikodijević, D. D., Milutinović, M. G., Cvetković, D. M., Ćupurdija, M. Đ., Jovanović, M. M., Mrkić, I. V., Gavrović-Jankulović, M.,& Marković, S. D.. (2021). Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. in Toxin Reviews
Taylor & Francis., 40(4), 1272-1279.
https://doi.org/10.1080/15569543.2019.1680564
Nikodijević DD, Milutinović MG, Cvetković DM, Ćupurdija MĐ, Jovanović MM, Mrkić IV, Gavrović-Jankulović M, Marković SD. Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. in Toxin Reviews. 2021;40(4):1272-1279.
doi:10.1080/15569543.2019.1680564 .
Nikodijević, Danijela D., Milutinović, Milena G., Cvetković, Danijela M., Ćupurdija, Maja Đ., Jovanović, Milena M., Mrkić, Ivan V., Gavrović-Jankulović, Marija, Marković, Snežana D., "Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines" in Toxin Reviews, 40, no. 4 (2021):1272-1279,
https://doi.org/10.1080/15569543.2019.1680564 . .

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