Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines
Authorized Users Only
2021
Authors
Nikodijević, Danijela D.Milutinović, Milena G.
Cvetković, Danijela M.
Ćupurdija, Maja Đ.
Jovanović, Milena M.
Mrkić, Ivan V.
Gavrović-Jankulović, Marija

Marković, Snežana D.

Article (Published version)

Metadata
Show full item recordAbstract
This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.
Keywords:
Animal products / apoptosis / cell death / honeybee / venomSource:
Toxin Reviews, 2021, 40, 4, 1272-1279Publisher:
- Taylor & Francis
Funding / projects:
- Preclinical investigation of bioactive substances (RS-41010)
- Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)
Note:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4975
Related info:
- Referenced by
https://cherry.chem.bg.ac.rs/handle/123456789/4975
DOI: 10.1080/15569543.2019.1680564
ISSN: 1556-9543
WoS: 000492116600001
Scopus: 2-s2.0-85074475935
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Nikodijević, Danijela D. AU - Milutinović, Milena G. AU - Cvetković, Danijela M. AU - Ćupurdija, Maja Đ. AU - Jovanović, Milena M. AU - Mrkić, Ivan V. AU - Gavrović-Jankulović, Marija AU - Marković, Snežana D. PY - 2021 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4974 AB - This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells. PB - Taylor & Francis T2 - Toxin Reviews T1 - Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines VL - 40 IS - 4 SP - 1272 EP - 1279 DO - 10.1080/15569543.2019.1680564 ER -
@article{ author = "Nikodijević, Danijela D. and Milutinović, Milena G. and Cvetković, Danijela M. and Ćupurdija, Maja Đ. and Jovanović, Milena M. and Mrkić, Ivan V. and Gavrović-Jankulović, Marija and Marković, Snežana D.", year = "2021", abstract = "This study provides data about anticancer properties of bee venom and its dominant compound, melittin on colorectal carcinoma cells (HCT-116 and SW-480) in regard to their proapoptotic activity and expression of genes involved in biotransformation process. Based on results, they are strong cytotoxins, where the melittin showed also selectivity against cancer cells compared to normal, HaCat. They induce proapoptotic activity by affecting apoptosis signaling molecules (Fas receptors, caspase 9, and members of Bcl-2 family of proteins) and mainly suppress expression of genes involved in their biotransformation, suggesting their ability to develop the resistance of colorectal cancer cells.", publisher = "Taylor & Francis", journal = "Toxin Reviews", title = "Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines", volume = "40", number = "4", pages = "1272-1279", doi = "10.1080/15569543.2019.1680564" }
Nikodijević, D. D., Milutinović, M. G., Cvetković, D. M., Ćupurdija, M. Đ., Jovanović, M. M., Mrkić, I. V., Gavrović-Jankulović, M.,& Marković, S. D.. (2021). Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. in Toxin Reviews Taylor & Francis., 40(4), 1272-1279. https://doi.org/10.1080/15569543.2019.1680564
Nikodijević DD, Milutinović MG, Cvetković DM, Ćupurdija MĐ, Jovanović MM, Mrkić IV, Gavrović-Jankulović M, Marković SD. Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines. in Toxin Reviews. 2021;40(4):1272-1279. doi:10.1080/15569543.2019.1680564 .
Nikodijević, Danijela D., Milutinović, Milena G., Cvetković, Danijela M., Ćupurdija, Maja Đ., Jovanović, Milena M., Mrkić, Ivan V., Gavrović-Jankulović, Marija, Marković, Snežana D., "Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines" in Toxin Reviews, 40, no. 4 (2021):1272-1279, https://doi.org/10.1080/15569543.2019.1680564 . .