Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?
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2022
Authors
Costa, Joana
Bavaro, Simona Lucia
Benedé, Sara

Diaz-Perales, Araceli
Bueno-Diaz, Cristina
Gelencser, Eva
Klueber, Julia
Larré, Colette
Lozano-Ojalvo, Daniel

Lupi, Roberta
Mafra, Isabel

Mazzucchelli, Gabriel

Molina, Elena

Monaci, Linda
Martín-Pedraza, Laura
Piras, Cristian
Rodrigues, Pedro M.
Roncada, Paola

Schrama, Denise
Ćirković-Veličković, Tanja

Verhoeckx, Kitty
Villa, Caterina

Kuehn, Annette
Hoffmann-Sommergruber, Karin

Holzhauser, Thomas
Article (Published version)

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Show full item recordAbstract
This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although... it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing.
Keywords:
Plant allergens / Protein families / Allergenicity / Food processing / Matrix effectSource:
Clinical Reviews in Allergy & Immunology, 2022, 62, 1, 37-63Publisher:
- Springer
Funding / projects:
- This article is based upon work from COST Action FA1402, supported by COST (www.cost.eu).
- Fundação para a Ciência e Tecnologia under the Partnership Agreement UIDB 50006/2020 and by the projects AlleRiskAssess - PTDC/BAA-AGR/31720/2017 and NORTE-01- 0145-FEDER-00001.
- FCT grants (PD/BD/ 114576/2016) financed by POPH-QREN (subsidised by FSE and MCTES).
- Molecular properties and modifications of some respiratory and nutritional allergens (RS-172024)
- FCT through project UIDB/04326/2020 and Mar2020 16–02-01-FMP0014 – ‘ALLYFISH’.
- PRIDE program grant (PRIDE/11012546/NEXTIMMUNE) by the Fonds National de la Recherche (FNR), Luxembourg and a translational grant (APSIS, PMC/2017/02) by the Personalised Medicine Consortium (PMC), Luxembourg.
Note:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4982
Related info:
- Referenced by
https://cherry.chem.bg.ac.rs/handle/123456789/4982
DOI: 10.1007/s12016-020-08810-9
ISSN: 1080-0549
WoS: 000565485300001
Scopus: 2-s2.0-85090224918
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Costa, Joana AU - Bavaro, Simona Lucia AU - Benedé, Sara AU - Diaz-Perales, Araceli AU - Bueno-Diaz, Cristina AU - Gelencser, Eva AU - Klueber, Julia AU - Larré, Colette AU - Lozano-Ojalvo, Daniel AU - Lupi, Roberta AU - Mafra, Isabel AU - Mazzucchelli, Gabriel AU - Molina, Elena AU - Monaci, Linda AU - Martín-Pedraza, Laura AU - Piras, Cristian AU - Rodrigues, Pedro M. AU - Roncada, Paola AU - Schrama, Denise AU - Ćirković-Veličković, Tanja AU - Verhoeckx, Kitty AU - Villa, Caterina AU - Kuehn, Annette AU - Hoffmann-Sommergruber, Karin AU - Holzhauser, Thomas PY - 2022 UR - https://doi.org/10.1007/s12016-020-08810-9 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4981 AB - This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing. PB - Springer T2 - Clinical Reviews in Allergy & Immunology T1 - Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens? VL - 62 IS - 1 SP - 37 EP - 63 DO - 10.1007/s12016-020-08810-9 ER -
@article{ author = "Costa, Joana and Bavaro, Simona Lucia and Benedé, Sara and Diaz-Perales, Araceli and Bueno-Diaz, Cristina and Gelencser, Eva and Klueber, Julia and Larré, Colette and Lozano-Ojalvo, Daniel and Lupi, Roberta and Mafra, Isabel and Mazzucchelli, Gabriel and Molina, Elena and Monaci, Linda and Martín-Pedraza, Laura and Piras, Cristian and Rodrigues, Pedro M. and Roncada, Paola and Schrama, Denise and Ćirković-Veličković, Tanja and Verhoeckx, Kitty and Villa, Caterina and Kuehn, Annette and Hoffmann-Sommergruber, Karin and Holzhauser, Thomas", year = "2022", abstract = "This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing.", publisher = "Springer", journal = "Clinical Reviews in Allergy & Immunology", title = "Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?", volume = "62", number = "1", pages = "37-63", doi = "10.1007/s12016-020-08810-9" }
Costa, J., Bavaro, S. L., Benedé, S., Diaz-Perales, A., Bueno-Diaz, C., Gelencser, E., Klueber, J., Larré, C., Lozano-Ojalvo, D., Lupi, R., Mafra, I., Mazzucchelli, G., Molina, E., Monaci, L., Martín-Pedraza, L., Piras, C., Rodrigues, P. M., Roncada, P., Schrama, D., Ćirković-Veličković, T., Verhoeckx, K., Villa, C., Kuehn, A., Hoffmann-Sommergruber, K.,& Holzhauser, T.. (2022). Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?. in Clinical Reviews in Allergy & Immunology Springer., 62(1), 37-63. https://doi.org/10.1007/s12016-020-08810-9
Costa J, Bavaro SL, Benedé S, Diaz-Perales A, Bueno-Diaz C, Gelencser E, Klueber J, Larré C, Lozano-Ojalvo D, Lupi R, Mafra I, Mazzucchelli G, Molina E, Monaci L, Martín-Pedraza L, Piras C, Rodrigues PM, Roncada P, Schrama D, Ćirković-Veličković T, Verhoeckx K, Villa C, Kuehn A, Hoffmann-Sommergruber K, Holzhauser T. Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?. in Clinical Reviews in Allergy & Immunology. 2022;62(1):37-63. doi:10.1007/s12016-020-08810-9 .
Costa, Joana, Bavaro, Simona Lucia, Benedé, Sara, Diaz-Perales, Araceli, Bueno-Diaz, Cristina, Gelencser, Eva, Klueber, Julia, Larré, Colette, Lozano-Ojalvo, Daniel, Lupi, Roberta, Mafra, Isabel, Mazzucchelli, Gabriel, Molina, Elena, Monaci, Linda, Martín-Pedraza, Laura, Piras, Cristian, Rodrigues, Pedro M., Roncada, Paola, Schrama, Denise, Ćirković-Veličković, Tanja, Verhoeckx, Kitty, Villa, Caterina, Kuehn, Annette, Hoffmann-Sommergruber, Karin, Holzhauser, Thomas, "Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?" in Clinical Reviews in Allergy & Immunology, 62, no. 1 (2022):37-63, https://doi.org/10.1007/s12016-020-08810-9 . .