Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?
Abstract
Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will... also be discussed in this review.
Keywords:
Exosomes / Exosome-mimetics / Drug delivery / Nanocarrier / Exosome-based drug delivery / Drug cargo-loadingSource:
Journal of Drug Delivery Science and Technology, 2022, 68, 103057-Publisher:
- Elsevier
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200288 (Innovation Center of the Faculty of Chemistry) (RS-200288)
Note:
- Peer-reviewed manuscript: https://cherry.chem.bg.ac.rs/handle/123456789/4997
DOI: 10.1016/j.jddst.2021.103057
ISSN: 1773-2247
WoS: 00078809030000
Scopus: 2-s2.0-85123953047
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - FIlipović, Lidija AU - Kojadinović, Milica I. AU - Popović, Milica M. PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4989 AB - Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review. PB - Elsevier T2 - Journal of Drug Delivery Science and Technology T1 - Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds? VL - 68 SP - 103057 DO - 10.1016/j.jddst.2021.103057 ER -
@article{ author = "FIlipović, Lidija and Kojadinović, Milica I. and Popović, Milica M.", year = "2022", abstract = "Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.", publisher = "Elsevier", journal = "Journal of Drug Delivery Science and Technology", title = "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?", volume = "68", pages = "103057", doi = "10.1016/j.jddst.2021.103057" }
FIlipović, L., Kojadinović, M. I.,& Popović, M. M.. (2022). Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?. in Journal of Drug Delivery Science and Technology Elsevier., 68, 103057. https://doi.org/10.1016/j.jddst.2021.103057
FIlipović L, Kojadinović MI, Popović MM. Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?. in Journal of Drug Delivery Science and Technology. 2022;68:103057. doi:10.1016/j.jddst.2021.103057 .
FIlipović, Lidija, Kojadinović, Milica I., Popović, Milica M., "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?" in Journal of Drug Delivery Science and Technology, 68 (2022):103057, https://doi.org/10.1016/j.jddst.2021.103057 . .
Related items
Showing items related by title, author, creator and subject.
-
Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?
FIlipović, Lidija; Kojadinović, Milica I.; Popović, Milica M. (Elsevier, 2022) -
Supplementary material for the article: Popovic, M.; Mazzega, E.; Toffoletto, B.; de Marco, A. Isolation of Anti-Extra-Cellular Vesicle Single-Domain Antibodies by Direct Panning on Vesicle-Enriched Fractions. Microbial cell factories 2018, 17 (1), 6. https://doi.org/10.1186/s12934-017-0856-9
Popović, Milica M.; Mazzega, Elisa; Toffoletto, Barbara; de Marco, Ario (Biomed Central Ltd, London, 2018) -
MiR-375 and miR-21 as Potential Biomarkers of Prostate Cancer: Comparison of Matching Samples of Plasma and Exosomes
Matijašević Joković, Suzana; Dobrijević, Zorana; Kotarac, Nevena; Filipović, Lidija; Popović, Milica M.; Korać, Aleksandra; Vuković, Ivan; Savić-Pavićević, Dušanka; Brajušković, Goran (MDPI, 2022)