Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will... also be discussed in this review.
Кључне речи:
Exosomes / Exosome-mimetics / Drug delivery / Nanocarrier / Exosome-based drug delivery / Drug cargo-loadingИзвор:
Journal of Drug Delivery Science and Technology, 2022, 68, 103057-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
Напомена:
- This is the peer-reviewed version of the following article: FIlipović, L.; Kojadinović, M. I.; Popović, M. M. Exosomes and Exosome-Mimetics as Targeted Drug Carriers: Where We Stand and What the Future Holds? Journal of Drug Delivery Science and Technology 2022, 68, 103057. https://doi.org/10.1016/j.jddst.2021.103057.
Повезане информације:
- Верзија документа
https://cherry.chem.bg.ac.rs/handle/123456789/4989 - Верзија документа
https://doi.org/10.1016/j.jddst.2021.103057
DOI: 10.1016/j.jddst.2021.103057
ISSN: 1773-2247
WoS: 00078809030000
Scopus: 2-s2.0-85123953047
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - FIlipović, Lidija AU - Kojadinović, Milica I. AU - Popović, Milica M. PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4997 AB - Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review. PB - Elsevier T2 - Journal of Drug Delivery Science and Technology T1 - Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds? VL - 68 SP - 103057 DO - 10.1016/j.jddst.2021.103057 ER -
@article{ author = "FIlipović, Lidija and Kojadinović, Milica I. and Popović, Milica M.", year = "2022", abstract = "Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.", publisher = "Elsevier", journal = "Journal of Drug Delivery Science and Technology", title = "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?", volume = "68", pages = "103057", doi = "10.1016/j.jddst.2021.103057" }
FIlipović, L., Kojadinović, M. I.,& Popović, M. M.. (2022). Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?. in Journal of Drug Delivery Science and Technology Elsevier., 68, 103057. https://doi.org/10.1016/j.jddst.2021.103057
FIlipović L, Kojadinović MI, Popović MM. Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?. in Journal of Drug Delivery Science and Technology. 2022;68:103057. doi:10.1016/j.jddst.2021.103057 .
FIlipović, Lidija, Kojadinović, Milica I., Popović, Milica M., "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?" in Journal of Drug Delivery Science and Technology, 68 (2022):103057, https://doi.org/10.1016/j.jddst.2021.103057 . .
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