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dc.creatorFIlipović, Lidija
dc.creatorKojadinović, Milica I.
dc.creatorPopović, Milica M.
dc.date.accessioned2022-04-14T13:33:10Z
dc.date.available2022-12-30
dc.date.issued2022
dc.identifier.issn1773-2247
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/4997
dc.description.abstractExosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200288/RS//sr
dc.relation.isversionofhttps://cherry.chem.bg.ac.rs/handle/123456789/4989
dc.relation.isversionofhttps://doi.org/10.1016/j.jddst.2021.103057
dc.rightsembargoedAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Drug Delivery Science and Technologysr
dc.subjectExosomessr
dc.subjectExosome-mimeticssr
dc.subjectDrug deliverysr
dc.subjectNanocarriersr
dc.subjectExosome-based drug deliverysr
dc.subjectDrug cargo-loadingsr
dc.titleExosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?sr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dc.citation.volume68
dc.citation.spage103057
dc.identifier.wos00078809030000
dc.identifier.doi10.1016/j.jddst.2021.103057
dc.description.otherThis is the peer-reviewed version of the following article: FIlipović, L.; Kojadinović, M. I.; Popović, M. M. Exosomes and Exosome-Mimetics as Targeted Drug Carriers: Where We Stand and What the Future Holds? Journal of Drug Delivery Science and Technology 2022, 68, 103057. [https://doi.org/10.1016/j.jddst.2021.103057].
dc.type.versionacceptedVersionsr
dc.identifier.scopus2-s2.0-85123953047


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