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Trans-platinum complexes as anticancer drugs: Recent developments and future prospects

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Authors
Radulović, Siniša
Tešić, Živoslav Lj.
Manic, S
Article (Published version)
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Abstract
Cisplatin represents one of the most potent drugs available in the cancer chemotherapy for several solid tumors, such as germ cell tumors, ovarian, lung, head and neck, and bladder cancers. Structure-activity relationship studies showed that leaving groups (generally chlorine) and two amine ligands in platinum complexes must be in the cis orientation and that the corresponding trans compounds are inactive. During the 1990's, several groups have reported trans-platinum compounds with in vitro growth inhibitory and in vivo antitumor properties. Some of these complexes were active against tumor cells resistant to cisplatin. More interestingly, there is a difference in cellular and biochemical pharmacology between trans-platinum complexes and cisplatin. Thus, monofunctional adducts might be related to the cytotoxicity of the trans-platinum-iminoether compounds against cis-DDP sensitive/resistant cell lines; unusual structure of long-range interstrand cross-links might be relevant for great... effectivity of bifunctional polinuclear trans-platinum(II) compounds against cis-DDP resistant variants. Trans-platinum compounds, appear to follow different pattern of cell killing in comparison to cisplatin, thus giving a reason for optimism in their development as a new class of platinum-based antitumor drugs.

Source:
Current Medicinal Chemistry, 2002, 9, 17, 1611-1618
Publisher:
  • Bentham Science Publ Ltd, Hilversum

DOI: 10.2174/0929867023369376

ISSN: 0929-8673

PubMed: 12171556

WoS: 000177436600004

Scopus: 2-s2.0-0035993852
[ Google Scholar ]
47
39
URI
https://cherry.chem.bg.ac.rs/handle/123456789/504
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Radulović, Siniša
AU  - Tešić, Živoslav Lj.
AU  - Manic, S
PY  - 2002
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/504
AB  - Cisplatin represents one of the most potent drugs available in the cancer chemotherapy for several solid tumors, such as germ cell tumors, ovarian, lung, head and neck, and bladder cancers. Structure-activity relationship studies showed that leaving groups (generally chlorine) and two amine ligands in platinum complexes must be in the cis orientation and that the corresponding trans compounds are inactive. During the 1990's, several groups have reported trans-platinum compounds with in vitro growth inhibitory and in vivo antitumor properties. Some of these complexes were active against tumor cells resistant to cisplatin. More interestingly, there is a difference in cellular and biochemical pharmacology between trans-platinum complexes and cisplatin. Thus, monofunctional adducts might be related to the cytotoxicity of the trans-platinum-iminoether compounds against cis-DDP sensitive/resistant cell lines; unusual structure of long-range interstrand cross-links might be relevant for great effectivity of bifunctional polinuclear trans-platinum(II) compounds against cis-DDP resistant variants. Trans-platinum compounds, appear to follow different pattern of cell killing in comparison to cisplatin, thus giving a reason for optimism in their development as a new class of platinum-based antitumor drugs.
PB  - Bentham Science Publ Ltd, Hilversum
T2  - Current Medicinal Chemistry
T1  - Trans-platinum complexes as anticancer drugs: Recent developments and future prospects
VL  - 9
IS  - 17
SP  - 1611
EP  - 1618
DO  - 10.2174/0929867023369376
UR  - Kon_1478
ER  - 
@article{
author = "Radulović, Siniša and Tešić, Živoslav Lj. and Manic, S",
year = "2002",
abstract = "Cisplatin represents one of the most potent drugs available in the cancer chemotherapy for several solid tumors, such as germ cell tumors, ovarian, lung, head and neck, and bladder cancers. Structure-activity relationship studies showed that leaving groups (generally chlorine) and two amine ligands in platinum complexes must be in the cis orientation and that the corresponding trans compounds are inactive. During the 1990's, several groups have reported trans-platinum compounds with in vitro growth inhibitory and in vivo antitumor properties. Some of these complexes were active against tumor cells resistant to cisplatin. More interestingly, there is a difference in cellular and biochemical pharmacology between trans-platinum complexes and cisplatin. Thus, monofunctional adducts might be related to the cytotoxicity of the trans-platinum-iminoether compounds against cis-DDP sensitive/resistant cell lines; unusual structure of long-range interstrand cross-links might be relevant for great effectivity of bifunctional polinuclear trans-platinum(II) compounds against cis-DDP resistant variants. Trans-platinum compounds, appear to follow different pattern of cell killing in comparison to cisplatin, thus giving a reason for optimism in their development as a new class of platinum-based antitumor drugs.",
publisher = "Bentham Science Publ Ltd, Hilversum",
journal = "Current Medicinal Chemistry",
title = "Trans-platinum complexes as anticancer drugs: Recent developments and future prospects",
volume = "9",
number = "17",
pages = "1611-1618",
doi = "10.2174/0929867023369376",
url = "Kon_1478"
}
Radulović, S., Tešić, Ž. Lj.,& Manic, S.. (2002). Trans-platinum complexes as anticancer drugs: Recent developments and future prospects. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Hilversum., 9(17), 1611-1618.
https://doi.org/10.2174/0929867023369376
Kon_1478
Radulović S, Tešić ŽL, Manic S. Trans-platinum complexes as anticancer drugs: Recent developments and future prospects. in Current Medicinal Chemistry. 2002;9(17):1611-1618.
doi:10.2174/0929867023369376
Kon_1478 .
Radulović, Siniša, Tešić, Živoslav Lj., Manic, S, "Trans-platinum complexes as anticancer drugs: Recent developments and future prospects" in Current Medicinal Chemistry, 9, no. 17 (2002):1611-1618,
https://doi.org/10.2174/0929867023369376 .,
Kon_1478 .

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