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dc.creatorÐurašević, Siniša
dc.creatorRužičić, Aleksandra
dc.creatorLakić, Iva
dc.creatorTosti, Tomislav
dc.creatorÐurović, Saša
dc.creatorGlumac, Sofija
dc.creatorPejić, Snežana
dc.creatorTodorović, Ana
dc.creatorDrakulić, Dunja
dc.creatorStanković, Sanja
dc.creatorJasnić, Nebojša
dc.creatorDević, Jelena Ð.
dc.creatorTodorović, Zoran B.
dc.date.accessioned2022-05-13T09:54:47Z
dc.date.available2022-05-13T09:54:47Z
dc.date.issued2022
dc.identifier.issn1661-6596
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/5076
dc.description.abstractA dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.languageEnglish
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200051/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200110/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectHeart
dc.subjectInflammation
dc.subjectKidney
dc.subjectLipidomics
dc.subjectLiver
dc.subjectOxidative stress
dc.subjectRats
dc.subjectSepsis
dc.titleThe Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats
dc.typearticleen
dc.rights.licenseBY
dc.citation.volume23
dc.citation.issue4
dc.identifier.wos000769724200001
dc.identifier.doi10.3390/ijms23042395
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85124899800
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/29704/The_Effects_of.pdf


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