Show simple item record

dc.creatorMarković, Maja D.
dc.creatorPanić, Vesna V.
dc.creatorSavić, Sanja I.
dc.creatorUgrinović, Vukašin Đ.
dc.creatorPjanović, Rada V.
dc.creatorSpasojević, Milica M.
dc.creatorSpasojevic, Pavle M.
dc.date.accessioned2022-05-20T09:04:18Z
dc.date.available2022-05-20T09:04:18Z
dc.date.issued2022
dc.identifier.issn1387-1811
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/5148
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/5150
dc.description.abstractMaterials sensitive to external stimuli are recognized as safe and effective tool able to respond to specific demands in the therapy of various diseases. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) are widely investigated for targeted drug delivery. Still, the abundance of the stimuli in the human body often requires more than one responsive group able to act simultaneously to achieve optimal therapeutic effects. Due to its pH sensitivity and bio-based production, crotonic acid (CA) was a monomer of choice for preparation of eco-friendly copolymer hydrogels based on NIPAAM and CA (P(NIPAAMcoCA)), which turned to be thermo and pH sensitive at the same time. The potential of the P(NIPAAMcoCA) system for encapsulation and controlled release of drugs with different solubility was investigated engaging water-soluble lidocaine hydrochloride and poorly water-soluble ibuprofen as model drugs. The hydrogels were characterized by various technics: FTIR, DSC, SEM and single compressive tests, while swelling behavior and controlled release of the drugs were analyzed with respect to the CA amount in two environments with different pH values at 25 °C and 37 °C. It was demonstrated that due to their dual responsiveness the P(NIPAAMcoCA) hydrogels have potential for controlled release of drugs with different solubility.
dc.languageEnglish
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200287/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200043/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200288/RS//
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.micromeso.2022.111817
dc.relation.isreferencedbyhttps://cherry.chem.bg.ac.rs/handle/123456789/5148
dc.rightsrestrictedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-sa/4.0/
dc.sourceMicroporous and Mesoporous Materials
dc.subjectCrotonic acid
dc.subjectDual responsive hydrogels
dc.subjectPoly(N-isopropylacrylamide)
dc.subjectSustainable materials
dc.subjectTargeted drug delivery
dc.titleSupplementary information for the article: Marković, M. D.; Panić, V. V.; Savić, S. I.; Ugrinović, V. Đ.; Pjanović, R. V.; Spasojević, M. M.; Spasojevic, P. M. Biobased Thermo/PH Sensitive Poly(N-Isopropylacrylamide-Co-Crotonic Acid) Hydrogels for Targeted Drug Delivery. Microporous and Mesoporous Materials 2022, 335. https://doi.org/10.1016.
dc.typedataseten
dc.rights.licenseBY-SA
dc.citation.volume335
dc.description.otherSupplementary material for: [https://doi.org/10.1016/j.micromeso.2022.111817]
dc.description.otherRelation to published version: [https://cherry.chem.bg.ac.rs/handle/123456789/5148]
dc.type.versionpublishedVersion
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_cherry_5150


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record