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Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke

Investigation of antiproliferative activity of new benzothiazolamine derivatives against MCF-7 human breast cancer cell line

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2016
53.SHD.pdf (911.4Kb)
Authors
Videnović, Milica
Srdić-Rajić, Tatjana
Opsenica, Igor
Radulović, Siniša
Šolaja, Bogdan
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Abstract
Poznato je da se mnogi lekovi, derivati benzotiazola, vrlo uspešno koriste u tretmanu različitih kliničkih stanja.1 Takođe, značajno mesto zauzimaju u istraživanjima antitumorskih agenasa i veliki broj strukturnih modifikacija jezgra benzotiazola načinjen je s ciljem poboljšanja njihove antitumorske aktivnosti. U okviru naših istraživanja u ovoj oblasti sintetisana je serija novih karbamata i amida 6-alkiltio-supstituisanih benzotiazolamina i ispitana je njihova antiproliferativna aktivnost prema MCF-7 ćelijskoj liniji humanog karcinoma dojke. Pokazano je da derivati benzotiazolamina izazivaju visoko specifičnu programiranu ćelijsku smrt apoptozu u značajnom procentu tretiranih MCF-7 ćelija. Ispitan je i uticaj novih jedinjenja na ćelijski ciklus, mitohondrijski membranski potencijal i nivo unutarćelijskih reaktivnih kiseoničnih vrsta
Numerous benzothiazole-based clinical drugs have been extensively used in practice to treat various type of diseases with high therapeutic efficacy.1 In addition, benzothiazole derivatives are compounds of an undoubted interest in anticancer research and a lot of structural modifications on their core nuclei have been made to improve their antitumor activety. Therefore, we have synthesized a series of novel 6-alkylthio-substituted benzothiazolamine carbamates and amides. To investigate their anticancer potency, we have used MCF7 human breast cancer cell line. Benzothiazolamine derivatives show great potency for promoting highly specific programmed cell death apoptosis in MCF-7 cancer cell line. Our research continued towards examination of our compounds influence on cell cycle phase distribution, reactive oxygen species level and mitochondrial membrane potential.
Source:
53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016., 2016, 99-99
Funding / projects:
  • The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)

ISBN: 978-86-7132-061-0

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_cherry_5347
URI
http://cherry.chem.bg.ac.rs/handle/123456789/5347
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  • Publikacije
Institution/Community
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TY  - CONF
AU  - Videnović, Milica
AU  - Srdić-Rajić, Tatjana
AU  - Opsenica, Igor
AU  - Radulović, Siniša
AU  - Šolaja, Bogdan
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5347
AB  - Poznato je da se mnogi lekovi, derivati benzotiazola, vrlo uspešno koriste u tretmanu
različitih kliničkih stanja.1
 Takođe, značajno mesto zauzimaju u istraživanjima
antitumorskih agenasa i veliki broj strukturnih modifikacija jezgra benzotiazola načinjen je
s ciljem poboljšanja njihove antitumorske aktivnosti. U okviru naših istraživanja u ovoj
oblasti sintetisana je serija novih karbamata i amida 6-alkiltio-supstituisanih
benzotiazolamina i ispitana je njihova antiproliferativna aktivnost prema MCF-7 ćelijskoj
liniji humanog karcinoma dojke. Pokazano je da derivati benzotiazolamina izazivaju visoko
specifičnu programiranu ćelijsku smrt apoptozu u značajnom procentu tretiranih MCF-7
ćelija. Ispitan je i uticaj novih jedinjenja na ćelijski ciklus, mitohondrijski membranski
potencijal i nivo unutarćelijskih reaktivnih kiseoničnih vrsta
AB  - Numerous benzothiazole-based clinical drugs have been extensively used in practice to
treat various type of diseases with high therapeutic efficacy.1
 In addition, benzothiazole derivatives are compounds of an undoubted interest in anticancer research and a lot of structural modifications on their core nuclei have been made to improve their antitumor activety. Therefore, we have synthesized a series of novel 6-alkylthio-substituted benzothiazolamine carbamates and amides. To investigate their anticancer potency, we have used MCF7 human breast cancer cell line. Benzothiazolamine derivatives show great potency for
promoting highly specific programmed cell death apoptosis in MCF-7 cancer cell line. Our
research continued towards examination of our compounds influence on cell cycle phase
distribution, reactive oxygen species level and mitochondrial membrane potential.
C3  - 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016.
T1  - Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke
T1  - Investigation of antiproliferative activity of new benzothiazolamine derivatives against MCF-7 human breast cancer cell line
SP  - 99
EP  - 99
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5347
ER  - 
@conference{
author = "Videnović, Milica and Srdić-Rajić, Tatjana and Opsenica, Igor and Radulović, Siniša and Šolaja, Bogdan",
year = "2016",
abstract = "Poznato je da se mnogi lekovi, derivati benzotiazola, vrlo uspešno koriste u tretmanu
različitih kliničkih stanja.1
 Takođe, značajno mesto zauzimaju u istraživanjima
antitumorskih agenasa i veliki broj strukturnih modifikacija jezgra benzotiazola načinjen je
s ciljem poboljšanja njihove antitumorske aktivnosti. U okviru naših istraživanja u ovoj
oblasti sintetisana je serija novih karbamata i amida 6-alkiltio-supstituisanih
benzotiazolamina i ispitana je njihova antiproliferativna aktivnost prema MCF-7 ćelijskoj
liniji humanog karcinoma dojke. Pokazano je da derivati benzotiazolamina izazivaju visoko
specifičnu programiranu ćelijsku smrt apoptozu u značajnom procentu tretiranih MCF-7
ćelija. Ispitan je i uticaj novih jedinjenja na ćelijski ciklus, mitohondrijski membranski
potencijal i nivo unutarćelijskih reaktivnih kiseoničnih vrsta, Numerous benzothiazole-based clinical drugs have been extensively used in practice to
treat various type of diseases with high therapeutic efficacy.1
 In addition, benzothiazole derivatives are compounds of an undoubted interest in anticancer research and a lot of structural modifications on their core nuclei have been made to improve their antitumor activety. Therefore, we have synthesized a series of novel 6-alkylthio-substituted benzothiazolamine carbamates and amides. To investigate their anticancer potency, we have used MCF7 human breast cancer cell line. Benzothiazolamine derivatives show great potency for
promoting highly specific programmed cell death apoptosis in MCF-7 cancer cell line. Our
research continued towards examination of our compounds influence on cell cycle phase
distribution, reactive oxygen species level and mitochondrial membrane potential.",
journal = "53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016.",
title = "Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke, Investigation of antiproliferative activity of new benzothiazolamine derivatives against MCF-7 human breast cancer cell line",
pages = "99-99",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5347"
}
Videnović, M., Srdić-Rajić, T., Opsenica, I., Radulović, S.,& Šolaja, B.. (2016). Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke. in 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016., 99-99.
https://hdl.handle.net/21.15107/rcub_cherry_5347
Videnović M, Srdić-Rajić T, Opsenica I, Radulović S, Šolaja B. Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke. in 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016.. 2016;:99-99.
https://hdl.handle.net/21.15107/rcub_cherry_5347 .
Videnović, Milica, Srdić-Rajić, Tatjana, Opsenica, Igor, Radulović, Siniša, Šolaja, Bogdan, "Ispitivanje antiproliferativne aktivnosti novih derivata benzotiazolamina prema MCF-7 ćelijskoj liniji humanog kancera dojke" in 53. Savetovanje Srpskog hemijskog društva, Prirodno-matematički fakultet, Kragujevac, 10. i 11. jun 2016. (2016):99-99,
https://hdl.handle.net/21.15107/rcub_cherry_5347 .

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