Estimation of the hydrophobicity of antimycotic compounds by planar chromatography
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The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.
Keywords:TLC / antimycotic compounds / hydrophobicity / QSAR
Source:Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2002, 15, 6, 414-417
- Research Inst Medicinal Plants, Budakalasz