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Reactivity of IGF binding protein-3 isoforms towards concanavalin A in healthy adults and subjects with cirrhosis
dc.creator | Nedić, Olgica | |
dc.creator | Nikolić, J. A. | |
dc.creator | Prisic, S | |
dc.creator | Aćimović, Jelena M. | |
dc.creator | Hajdukovic-Dragojlovic, L | |
dc.date.accessioned | 2018-11-22T00:05:58Z | |
dc.date.available | 2018-11-22T00:05:58Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 1355-6215 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/543 | |
dc.description.abstract | The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophoresis and ligand blotting demonstrated that there was a gradual change in carbohydrate properties of putative IGFBP-3 with progression of ALC from stages A to C. As many as 12 ionic species of IGFBP-3 could be distinguished, corresponding probably to variously glycosylated and/or phosphorylated isoforms of the core protein. Three of them reacted significantly with the immobilized Con A, the pattern being altered in patients with ALC. Patients with ALC in stage B exhibited the presence of clearly differentiated IGFBP-3 variants less and more Con A reactive, suggesting this stage to be a turning point with the most intensive changes in the IGF-IGFBP system. Because the glycosylation pattern is tissue specific, pathological post-translational modifications found for one glycoprotein (IGFBP-3) are probably shared by others of the same tissue origin. This may affect their susceptibility to proteolysis and subsequently their function. | en |
dc.publisher | Carfax Publishing, Basingstoke | |
dc.rights | restrictedAccess | |
dc.source | Addiction Biology | |
dc.title | Reactivity of IGF binding protein-3 isoforms towards concanavalin A in healthy adults and subjects with cirrhosis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Николиц, ЈA; Присиц, С; Aћимовић, Јелена; Хајдуковиц-Драгојловиц, Л; Недиц, О; | |
dc.citation.volume | 8 | |
dc.citation.issue | 1 | |
dc.citation.spage | 81 | |
dc.citation.epage | 88 | |
dc.identifier.wos | 000181603600011 | |
dc.identifier.doi | 10.1080/1355621031000069927 | |
dc.citation.other | 8(1): 81-88 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 12745420 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-0037360212 |
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