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Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes
dc.creator | Opsenica, Dejan M. | |
dc.creator | Angelovski, G | |
dc.creator | Pocsfalvi, G | |
dc.creator | Juranić, Z. | |
dc.creator | Žižak, Željko S. | |
dc.creator | Kyle, D | |
dc.creator | Milhous, WK | |
dc.creator | Šolaja, Bogdan A. | |
dc.date.accessioned | 2018-11-22T00:06:14Z | |
dc.date.available | 2018-11-22T00:06:14Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/559 | |
dc.description.abstract | Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei). (C) 2003 Elsevier Science Ltd. All rights reserved. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry | |
dc.title | Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милхоус, WК; Кyле, Д; Поцсфалви, Г; Шолаја, Богдан A.; Јураниц, З; Зизак, З; Aнгеловски, Г; Опсеница, Р; | |
dc.citation.volume | 11 | |
dc.citation.issue | 13 | |
dc.citation.spage | 2761 | |
dc.citation.epage | 2768 | |
dc.identifier.wos | 000183590100011 | |
dc.identifier.doi | 10.1016/S0968-0896(03)00224-4 | |
dc.citation.other | 11(13): 2761-2768 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 12788350 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-0037871977 |
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