Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid
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Natić, MajaTešić, Živoslav Lj.
Anđelković, Katarina K.
Brčeski, Ilija
Radulović, Siniša
Manic, S
Sladić, Dušan
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The complexes of Pd(II) and Cu(II) with the condensation products of usnic acid with hydrazides were prepared and characterized by elemental analyses, IR, H-1 NMR, and C-13 NMR spectroscopy. In all cases, the complexes appear to be monomeric and square-planar, with three binding sites occupied by the dianionic tridentate ligand, and the fourth position occupied by ethanol. The complexes were tested for in vitro growth inhibitory activity against Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis and were found to possess significant activity. The cytotoxic tests were carried out by utilization of the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) microculture colorimetric assay in which human cervix carcinoma HeLa cells were treated by continuous exposure (48 h) to the test agents. All investigated compounds showed cytotoxic activity against HeLa cells with IC50 values between 1.8 and 86.0 muM.
Keywords:
usnic acid / Pd(II) complex / Cu(II) complex / biological activity / synthesisSource:
Synthesis and Reactivity in Inorganic and Metal-organic Chemistry, 2004, 34, 1, 101-113Publisher:
- Marcel Dekker Inc, New York
DOI: 10.1081/SIM-120027320
ISSN: 0094-5714
WoS: 000189254200007
Scopus: 2-s2.0-1642396487
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Natić, Maja AU - Tešić, Živoslav Lj. AU - Anđelković, Katarina K. AU - Brčeski, Ilija AU - Radulović, Siniša AU - Manic, S AU - Sladić, Dušan PY - 2004 UR - https://cherry.chem.bg.ac.rs/handle/123456789/571 AB - The complexes of Pd(II) and Cu(II) with the condensation products of usnic acid with hydrazides were prepared and characterized by elemental analyses, IR, H-1 NMR, and C-13 NMR spectroscopy. In all cases, the complexes appear to be monomeric and square-planar, with three binding sites occupied by the dianionic tridentate ligand, and the fourth position occupied by ethanol. The complexes were tested for in vitro growth inhibitory activity against Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis and were found to possess significant activity. The cytotoxic tests were carried out by utilization of the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) microculture colorimetric assay in which human cervix carcinoma HeLa cells were treated by continuous exposure (48 h) to the test agents. All investigated compounds showed cytotoxic activity against HeLa cells with IC50 values between 1.8 and 86.0 muM. PB - Marcel Dekker Inc, New York T2 - Synthesis and Reactivity in Inorganic and Metal-organic Chemistry T1 - Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid VL - 34 IS - 1 SP - 101 EP - 113 DO - 10.1081/SIM-120027320 ER -
@article{ author = "Natić, Maja and Tešić, Živoslav Lj. and Anđelković, Katarina K. and Brčeski, Ilija and Radulović, Siniša and Manic, S and Sladić, Dušan", year = "2004", abstract = "The complexes of Pd(II) and Cu(II) with the condensation products of usnic acid with hydrazides were prepared and characterized by elemental analyses, IR, H-1 NMR, and C-13 NMR spectroscopy. In all cases, the complexes appear to be monomeric and square-planar, with three binding sites occupied by the dianionic tridentate ligand, and the fourth position occupied by ethanol. The complexes were tested for in vitro growth inhibitory activity against Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis and were found to possess significant activity. The cytotoxic tests were carried out by utilization of the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) microculture colorimetric assay in which human cervix carcinoma HeLa cells were treated by continuous exposure (48 h) to the test agents. All investigated compounds showed cytotoxic activity against HeLa cells with IC50 values between 1.8 and 86.0 muM.", publisher = "Marcel Dekker Inc, New York", journal = "Synthesis and Reactivity in Inorganic and Metal-organic Chemistry", title = "Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid", volume = "34", number = "1", pages = "101-113", doi = "10.1081/SIM-120027320" }
Natić, M., Tešić, Ž. Lj., Anđelković, K. K., Brčeski, I., Radulović, S., Manic, S.,& Sladić, D.. (2004). Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid. in Synthesis and Reactivity in Inorganic and Metal-organic Chemistry Marcel Dekker Inc, New York., 34(1), 101-113. https://doi.org/10.1081/SIM-120027320
Natić M, Tešić ŽL, Anđelković KK, Brčeski I, Radulović S, Manic S, Sladić D. Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid. in Synthesis and Reactivity in Inorganic and Metal-organic Chemistry. 2004;34(1):101-113. doi:10.1081/SIM-120027320 .
Natić, Maja, Tešić, Živoslav Lj., Anđelković, Katarina K., Brčeski, Ilija, Radulović, Siniša, Manic, S, Sladić, Dušan, "Synthesis and biological activity of Pd(II) and Cu(II) complexes with acylhydrazones of usnic acid" in Synthesis and Reactivity in Inorganic and Metal-organic Chemistry, 34, no. 1 (2004):101-113, https://doi.org/10.1081/SIM-120027320 . .