Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?
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2022
Authors
Costa, Joana
Villa, Caterina

Verhoeckx, Kitty
Ćirković-Veličković, Tanja

Schrama, Denise
Roncada, Paola

Rodrigues, Pedro M.
Piras, Cristian
Martín-Pedraza, Laura
Monaci, Linda
Molina, Elena

Mazzucchelli, Gabriel

Mafra, Isabel

Lupi, Roberta
Lozano-Ojalvo, Daniel

Larré, Colette
Klueber, Julia
Gelencser, Eva
Bueno-Diaz, Cristina
Diaz-Perales, Araceli
Benedé, Sara

Bavaro, Simona Lucia
Kuehn, Annette
Hoffmann-Sommergruber, Karin
Holzhauser, Thomas
Article (Published version)

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Key determinants for the development of an allergic response to an otherwise ‘harmless’ food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens.
Keywords:
Animal allergens / Protein families / Allergenicity / Food processing / Allergen integritySource:
Clinical Reviews in Allergy & Immunology, 2022, 62, 1, 1-36Funding / projects:
- Fundação para a Ciência e Tecnologia under the Partnership Agreement UIDB 50006/2020.
- AlleRiskAssess— PTDC/BAA-AGR/31720/2017.
- FCT grant (PD/ BD/114576/2016) fnanced by POPH-QREN (subsidised by FSE and MCTES).
- FCT research contract (SFRH/ BPD/102404/2014).
- Molecular properties and modifications of some respiratory and nutritional allergens (RS-172024)
- FCT project UIDB/04326/2020 and Mar2020 16-02-01-FMP0014—“ALLYFISH”.
- PRIDE program grants (PRIDE/11012546/NEXTIMMUNE).
- FNR (Fonds National de la Recherche).
- PMC (Personalised Medicine Consortium).
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Costa, Joana AU - Villa, Caterina AU - Verhoeckx, Kitty AU - Ćirković-Veličković, Tanja AU - Schrama, Denise AU - Roncada, Paola AU - Rodrigues, Pedro M. AU - Piras, Cristian AU - Martín-Pedraza, Laura AU - Monaci, Linda AU - Molina, Elena AU - Mazzucchelli, Gabriel AU - Mafra, Isabel AU - Lupi, Roberta AU - Lozano-Ojalvo, Daniel AU - Larré, Colette AU - Klueber, Julia AU - Gelencser, Eva AU - Bueno-Diaz, Cristina AU - Diaz-Perales, Araceli AU - Benedé, Sara AU - Bavaro, Simona Lucia AU - Kuehn, Annette AU - Hoffmann-Sommergruber, Karin AU - Holzhauser, Thomas PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5791 AB - Key determinants for the development of an allergic response to an otherwise ‘harmless’ food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens. T2 - Clinical Reviews in Allergy & Immunology T1 - Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens? VL - 62 IS - 1 SP - 1 EP - 36 DO - 10.1007/s12016-020-08826-1 ER -
@article{ author = "Costa, Joana and Villa, Caterina and Verhoeckx, Kitty and Ćirković-Veličković, Tanja and Schrama, Denise and Roncada, Paola and Rodrigues, Pedro M. and Piras, Cristian and Martín-Pedraza, Laura and Monaci, Linda and Molina, Elena and Mazzucchelli, Gabriel and Mafra, Isabel and Lupi, Roberta and Lozano-Ojalvo, Daniel and Larré, Colette and Klueber, Julia and Gelencser, Eva and Bueno-Diaz, Cristina and Diaz-Perales, Araceli and Benedé, Sara and Bavaro, Simona Lucia and Kuehn, Annette and Hoffmann-Sommergruber, Karin and Holzhauser, Thomas", year = "2022", abstract = "Key determinants for the development of an allergic response to an otherwise ‘harmless’ food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens.", journal = "Clinical Reviews in Allergy & Immunology", title = "Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?", volume = "62", number = "1", pages = "1-36", doi = "10.1007/s12016-020-08826-1" }
Costa, J., Villa, C., Verhoeckx, K., Ćirković-Veličković, T., Schrama, D., Roncada, P., Rodrigues, P. M., Piras, C., Martín-Pedraza, L., Monaci, L., Molina, E., Mazzucchelli, G., Mafra, I., Lupi, R., Lozano-Ojalvo, D., Larré, C., Klueber, J., Gelencser, E., Bueno-Diaz, C., Diaz-Perales, A., Benedé, S., Bavaro, S. L., Kuehn, A., Hoffmann-Sommergruber, K.,& Holzhauser, T.. (2022). Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?. in Clinical Reviews in Allergy & Immunology, 62(1), 1-36. https://doi.org/10.1007/s12016-020-08826-1
Costa J, Villa C, Verhoeckx K, Ćirković-Veličković T, Schrama D, Roncada P, Rodrigues PM, Piras C, Martín-Pedraza L, Monaci L, Molina E, Mazzucchelli G, Mafra I, Lupi R, Lozano-Ojalvo D, Larré C, Klueber J, Gelencser E, Bueno-Diaz C, Diaz-Perales A, Benedé S, Bavaro SL, Kuehn A, Hoffmann-Sommergruber K, Holzhauser T. Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?. in Clinical Reviews in Allergy & Immunology. 2022;62(1):1-36. doi:10.1007/s12016-020-08826-1 .
Costa, Joana, Villa, Caterina, Verhoeckx, Kitty, Ćirković-Veličković, Tanja, Schrama, Denise, Roncada, Paola, Rodrigues, Pedro M., Piras, Cristian, Martín-Pedraza, Laura, Monaci, Linda, Molina, Elena, Mazzucchelli, Gabriel, Mafra, Isabel, Lupi, Roberta, Lozano-Ojalvo, Daniel, Larré, Colette, Klueber, Julia, Gelencser, Eva, Bueno-Diaz, Cristina, Diaz-Perales, Araceli, Benedé, Sara, Bavaro, Simona Lucia, Kuehn, Annette, Hoffmann-Sommergruber, Karin, Holzhauser, Thomas, "Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?" in Clinical Reviews in Allergy & Immunology, 62, no. 1 (2022):1-36, https://doi.org/10.1007/s12016-020-08826-1 . .
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