Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores
Ribofuranoza kao nosač tetraoksanske i 4-aminohinolinske antimalarijske farmakofore
Apstrakt
Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).
U ovom radu prikazana je sinteza nekoliko ribofuranozidnih tetraoksana i 4-aminohinolina u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja su pokazala izraženu antimalarijsku aktivnost prema hlorokin-osetljivom (D6), hlorokin-rezistentnom (W2) i višestruko rezistentnom (TM91C235 (Thailand)) soju Plasmodium falciparum. Aminohinolinski derivat 4 je aktivniji prema W2 i TM91C235 sojevima od kontrolnih jedinjenja (hlorokin i meflokin).
Ključne reči:
tetraoxanes / 4-aminoquinolines / 4-aminoquinolines / malaria / malaria / P. falciparum / P. falciparumIzvor:
Journal of the Serbian Chemical Society, 2008, 73, 11, 1021-1025Izdavač:
- Serbian Chemical Soc, Belgrade
Finansiranje / projekti:
- Peroksidni antimalarici i njihove himere sa hinolinima: sinteza i biološka aktivnost (RS-MESTD-MPN2006-2010-142022)
- Serbian Academy of Sciences and Arts
DOI: 10.2298/JSC0811021O
ISSN: 0352-5139
WoS: 000261070600001
Scopus: 2-s2.0-55549130272
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Opsenica, Igor AU - Smith, Kirsten K. AU - Gerena, Lucia AU - Gaica, Sandra AU - Šolaja, Bogdan A. PY - 2008 UR - https://cherry.chem.bg.ac.rs/handle/123456789/587 AB - Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ). AB - U ovom radu prikazana je sinteza nekoliko ribofuranozidnih tetraoksana i 4-aminohinolina u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja su pokazala izraženu antimalarijsku aktivnost prema hlorokin-osetljivom (D6), hlorokin-rezistentnom (W2) i višestruko rezistentnom (TM91C235 (Thailand)) soju Plasmodium falciparum. Aminohinolinski derivat 4 je aktivniji prema W2 i TM91C235 sojevima od kontrolnih jedinjenja (hlorokin i meflokin). PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores T1 - Ribofuranoza kao nosač tetraoksanske i 4-aminohinolinske antimalarijske farmakofore VL - 73 IS - 11 SP - 1021 EP - 1025 DO - 10.2298/JSC0811021O ER -
@article{ author = "Opsenica, Igor and Smith, Kirsten K. and Gerena, Lucia and Gaica, Sandra and Šolaja, Bogdan A.", year = "2008", abstract = "Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ)., U ovom radu prikazana je sinteza nekoliko ribofuranozidnih tetraoksana i 4-aminohinolina u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja su pokazala izraženu antimalarijsku aktivnost prema hlorokin-osetljivom (D6), hlorokin-rezistentnom (W2) i višestruko rezistentnom (TM91C235 (Thailand)) soju Plasmodium falciparum. Aminohinolinski derivat 4 je aktivniji prema W2 i TM91C235 sojevima od kontrolnih jedinjenja (hlorokin i meflokin).", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores, Ribofuranoza kao nosač tetraoksanske i 4-aminohinolinske antimalarijske farmakofore", volume = "73", number = "11", pages = "1021-1025", doi = "10.2298/JSC0811021O" }
Opsenica, I., Smith, K. K., Gerena, L., Gaica, S.,& Šolaja, B. A.. (2008). Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 73(11), 1021-1025. https://doi.org/10.2298/JSC0811021O
Opsenica I, Smith KK, Gerena L, Gaica S, Šolaja BA. Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores. in Journal of the Serbian Chemical Society. 2008;73(11):1021-1025. doi:10.2298/JSC0811021O .
Opsenica, Igor, Smith, Kirsten K., Gerena, Lucia, Gaica, Sandra, Šolaja, Bogdan A., "Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores" in Journal of the Serbian Chemical Society, 73, no. 11 (2008):1021-1025, https://doi.org/10.2298/JSC0811021O . .