Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes
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2023
Authors
Dimitrijević, MarijaMihajlović-Lalić, Ljiljana

Grgurić-Šipka, Sanja

Mihajlov-Krstev, Tatjana
Miladinović, Dragoljub
Poljarević, Jelena

Article (Published version)

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Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized using [Ru(g6-benzene)Cl(l-Cl)]2 and
[Ru(g6-toluene)Cl(l-Cl)]2 and four pyridine carboxylic acid-based
ligands (dicarboxylic acids and halogen derivatives). The structures
and purity of synthesized compounds were confirmed using 1H
and 13C NMR spectroscopy, infrared spectroscopy, mass spectrometry, and elemental analysis. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H
NMR spectroscopy. The seven ligands, two complex precursors
(CP1 and CP2), and 14 half-sandwich Ru(II) picolinate complexes
(C1–C14) were evaluated for in vitro antibacterial and antifungal
activity against pathogens, such as Staphylococcus aureus, Bacillus
cereus, Proteus mirabilis, Klebsiella pneumoniae, Ecsherichia coli,
Pseudomonas aeruginosa, Salmonella enteritidis, Enterobacter aerogenes, and yeast Candida albicans, using the microwell-dilution
method. Among the tested samples, ...the ligands showed better
inhibitory effect against Gram-positive bacteria when compared
to the metal complexes. The most susceptible Gram-negative bacteria was Ecsherichia coli, with a MIC value of 1.25 mg/mL, for C3,
C6, and C10. All synthesized complexes showed similar, slightly
better activity against Candida albicans.
Keywords:
Arene Ru(II) complex / picolinic acid / antibacterial activity / antifungal activity / NMR spectroscopySource:
Journal of Coordination Chemistry, 2023, 76, 5-6, 783-797Publisher:
- Taylor & Francis
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200288 (Innovation Center of the Faculty of Chemistry) (RS-200288)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200113 (Univeristy of Niš, Faculty of Medicine) (RS-200113)
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Dimitrijević, Marija AU - Mihajlović-Lalić, Ljiljana AU - Grgurić-Šipka, Sanja AU - Mihajlov-Krstev, Tatjana AU - Miladinović, Dragoljub AU - Poljarević, Jelena PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5903 AB - Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized using [Ru(g6-benzene)Cl(l-Cl)]2 and [Ru(g6-toluene)Cl(l-Cl)]2 and four pyridine carboxylic acid-based ligands (dicarboxylic acids and halogen derivatives). The structures and purity of synthesized compounds were confirmed using 1H and 13C NMR spectroscopy, infrared spectroscopy, mass spectrometry, and elemental analysis. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H NMR spectroscopy. The seven ligands, two complex precursors (CP1 and CP2), and 14 half-sandwich Ru(II) picolinate complexes (C1–C14) were evaluated for in vitro antibacterial and antifungal activity against pathogens, such as Staphylococcus aureus, Bacillus cereus, Proteus mirabilis, Klebsiella pneumoniae, Ecsherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis, Enterobacter aerogenes, and yeast Candida albicans, using the microwell-dilution method. Among the tested samples, the ligands showed better inhibitory effect against Gram-positive bacteria when compared to the metal complexes. The most susceptible Gram-negative bacteria was Ecsherichia coli, with a MIC value of 1.25 mg/mL, for C3, C6, and C10. All synthesized complexes showed similar, slightly better activity against Candida albicans. PB - Taylor & Francis T2 - Journal of Coordination Chemistry T1 - Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes VL - 76 IS - 5-6 SP - 783 EP - 797 DO - 10.1080/00958972.2023.2195965 ER -
@article{ author = "Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Grgurić-Šipka, Sanja and Mihajlov-Krstev, Tatjana and Miladinović, Dragoljub and Poljarević, Jelena", year = "2023", abstract = "Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized using [Ru(g6-benzene)Cl(l-Cl)]2 and [Ru(g6-toluene)Cl(l-Cl)]2 and four pyridine carboxylic acid-based ligands (dicarboxylic acids and halogen derivatives). The structures and purity of synthesized compounds were confirmed using 1H and 13C NMR spectroscopy, infrared spectroscopy, mass spectrometry, and elemental analysis. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H NMR spectroscopy. The seven ligands, two complex precursors (CP1 and CP2), and 14 half-sandwich Ru(II) picolinate complexes (C1–C14) were evaluated for in vitro antibacterial and antifungal activity against pathogens, such as Staphylococcus aureus, Bacillus cereus, Proteus mirabilis, Klebsiella pneumoniae, Ecsherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis, Enterobacter aerogenes, and yeast Candida albicans, using the microwell-dilution method. Among the tested samples, the ligands showed better inhibitory effect against Gram-positive bacteria when compared to the metal complexes. The most susceptible Gram-negative bacteria was Ecsherichia coli, with a MIC value of 1.25 mg/mL, for C3, C6, and C10. All synthesized complexes showed similar, slightly better activity against Candida albicans.", publisher = "Taylor & Francis", journal = "Journal of Coordination Chemistry", title = "Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes", volume = "76", number = "5-6", pages = "783-797", doi = "10.1080/00958972.2023.2195965" }
Dimitrijević, M., Mihajlović-Lalić, L., Grgurić-Šipka, S., Mihajlov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2023). Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 76(5-6), 783-797. https://doi.org/10.1080/00958972.2023.2195965
Dimitrijević M, Mihajlović-Lalić L, Grgurić-Šipka S, Mihajlov-Krstev T, Miladinović D, Poljarević J. Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes. in Journal of Coordination Chemistry. 2023;76(5-6):783-797. doi:10.1080/00958972.2023.2195965 .
Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Grgurić-Šipka, Sanja, Mihajlov-Krstev, Tatjana, Miladinović, Dragoljub, Poljarević, Jelena, "Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes" in Journal of Coordination Chemistry, 76, no. 5-6 (2023):783-797, https://doi.org/10.1080/00958972.2023.2195965 . .