Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency
Ru(II) arenski kompleksi sa piridinskim ligandima: sinteza i antimikrobna aktivnost
Authors
Dimitrijević, MarijaMihajlović-Lalić, Ljiljana
Grgurić-Šipka, Sanja

Nikolić, Stefan

Petrović, Tamara
Poljarević, Jelena

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Metal-based compounds are rarely good antimicrobial compounds. Here we report
synthesis, chemical characterization and antimicrobial potency of fourteen Ru(II) arene
complexes with pyridine-based ligands. The structures and purity of synthesized
compounds were confirmed using 1H and 13C NMR spectroscopy, IR spectroscopy, MS, and
EA. A micro-well dilution assay was used to determine the minimum inhibitory
concentration (MIC), and minimum bactericidal concentration. of evaluated compounds.
Streptomycin and chloramphenicol were used as a positive control. The best activity of all
tested bacteria was observed against E. coli, with a MIC value of 1.25 mg/mL, for
complexes with 2,4- i 2,5-pyridinedicarboxylic ligands. Also, all synthesized complexes
showed the same activity against C. Albicans.
Kompleksi metala retko se koriste kao potencijalni antimikrobni agensi. U ovom radu smo prikazali sintezu, hemijsku karakterizaciju i antimikrobnu aktivnost 14 arenskih Ru(II) kompleksa sa piridinskim ligandima. Strukturu i čistoću dobijenih jedinjenja potvrdili smo koristeći 1H, 13C NMR i IC spektroskopiju, MS i EA. Mikrodilucioni esej je korišćen za određivanje minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne koncentracije sintetisanih jedinjenja. Streptomicin i hloramfenikol su korišćeni kao standard. Najbolja aktivnost prema ispitivanim sojevima bakterija zapažena je na soju E. coli, sa MIC vrednošću 1,25 mg/mL, kompleksa sa 2,4- i 2,5-piridindikarboksilnim ligandima. Svi sintetisani kompleksi pokazali su podjednako dobru aktivnost prema C. Albicans.
Source:
59. Savetovanje srpskog hemijskog društva, 2023, 74-74Publisher:
- Belgrade : Serbian Chemical Society
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200288 (Innovation Center of the Faculty of Chemistry) (RS-200288)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200113 (Univeristy of Niš, Faculty of Medicine) (RS-200113)
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Hemijski fakultet / Faculty of ChemistryTY - CONF AU - Dimitrijević, Marija AU - Mihajlović-Lalić, Ljiljana AU - Grgurić-Šipka, Sanja AU - Nikolić, Stefan AU - Petrović, Tamara AU - Poljarević, Jelena PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5904 AB - Metal-based compounds are rarely good antimicrobial compounds. Here we report synthesis, chemical characterization and antimicrobial potency of fourteen Ru(II) arene complexes with pyridine-based ligands. The structures and purity of synthesized compounds were confirmed using 1H and 13C NMR spectroscopy, IR spectroscopy, MS, and EA. A micro-well dilution assay was used to determine the minimum inhibitory concentration (MIC), and minimum bactericidal concentration. of evaluated compounds. Streptomycin and chloramphenicol were used as a positive control. The best activity of all tested bacteria was observed against E. coli, with a MIC value of 1.25 mg/mL, for complexes with 2,4- i 2,5-pyridinedicarboxylic ligands. Also, all synthesized complexes showed the same activity against C. Albicans. AB - Kompleksi metala retko se koriste kao potencijalni antimikrobni agensi. U ovom radu smo prikazali sintezu, hemijsku karakterizaciju i antimikrobnu aktivnost 14 arenskih Ru(II) kompleksa sa piridinskim ligandima. Strukturu i čistoću dobijenih jedinjenja potvrdili smo koristeći 1H, 13C NMR i IC spektroskopiju, MS i EA. Mikrodilucioni esej je korišćen za određivanje minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne koncentracije sintetisanih jedinjenja. Streptomicin i hloramfenikol su korišćeni kao standard. Najbolja aktivnost prema ispitivanim sojevima bakterija zapažena je na soju E. coli, sa MIC vrednošću 1,25 mg/mL, kompleksa sa 2,4- i 2,5-piridindikarboksilnim ligandima. Svi sintetisani kompleksi pokazali su podjednako dobru aktivnost prema C. Albicans. PB - Belgrade : Serbian Chemical Society C3 - 59. Savetovanje srpskog hemijskog društva T1 - Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency SP - 74 EP - 74 UR - https://hdl.handle.net/21.15107/rcub_cherry_5904 ER -
@conference{ author = "Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Grgurić-Šipka, Sanja and Nikolić, Stefan and Petrović, Tamara and Poljarević, Jelena", year = "2023", abstract = "Metal-based compounds are rarely good antimicrobial compounds. Here we report synthesis, chemical characterization and antimicrobial potency of fourteen Ru(II) arene complexes with pyridine-based ligands. The structures and purity of synthesized compounds were confirmed using 1H and 13C NMR spectroscopy, IR spectroscopy, MS, and EA. A micro-well dilution assay was used to determine the minimum inhibitory concentration (MIC), and minimum bactericidal concentration. of evaluated compounds. Streptomycin and chloramphenicol were used as a positive control. The best activity of all tested bacteria was observed against E. coli, with a MIC value of 1.25 mg/mL, for complexes with 2,4- i 2,5-pyridinedicarboxylic ligands. Also, all synthesized complexes showed the same activity against C. Albicans., Kompleksi metala retko se koriste kao potencijalni antimikrobni agensi. U ovom radu smo prikazali sintezu, hemijsku karakterizaciju i antimikrobnu aktivnost 14 arenskih Ru(II) kompleksa sa piridinskim ligandima. Strukturu i čistoću dobijenih jedinjenja potvrdili smo koristeći 1H, 13C NMR i IC spektroskopiju, MS i EA. Mikrodilucioni esej je korišćen za određivanje minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne koncentracije sintetisanih jedinjenja. Streptomicin i hloramfenikol su korišćeni kao standard. Najbolja aktivnost prema ispitivanim sojevima bakterija zapažena je na soju E. coli, sa MIC vrednošću 1,25 mg/mL, kompleksa sa 2,4- i 2,5-piridindikarboksilnim ligandima. Svi sintetisani kompleksi pokazali su podjednako dobru aktivnost prema C. Albicans.", publisher = "Belgrade : Serbian Chemical Society", journal = "59. Savetovanje srpskog hemijskog društva", title = "Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency", pages = "74-74", url = "https://hdl.handle.net/21.15107/rcub_cherry_5904" }
Dimitrijević, M., Mihajlović-Lalić, L., Grgurić-Šipka, S., Nikolić, S., Petrović, T.,& Poljarević, J.. (2023). Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency. in 59. Savetovanje srpskog hemijskog društva Belgrade : Serbian Chemical Society., 74-74. https://hdl.handle.net/21.15107/rcub_cherry_5904
Dimitrijević M, Mihajlović-Lalić L, Grgurić-Šipka S, Nikolić S, Petrović T, Poljarević J. Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency. in 59. Savetovanje srpskog hemijskog društva. 2023;:74-74. https://hdl.handle.net/21.15107/rcub_cherry_5904 .
Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Grgurić-Šipka, Sanja, Nikolić, Stefan, Petrović, Tamara, Poljarević, Jelena, "Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency" in 59. Savetovanje srpskog hemijskog društva (2023):74-74, https://hdl.handle.net/21.15107/rcub_cherry_5904 .