Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency

Abstract

Metal-based compounds are rarely good antimicrobial compounds. Here we report synthesis, chemical characterization and antimicrobial potency of fourteen Ru(II) arene complexes with pyridine-based ligands. The structures and purity of synthesized compounds were confirmed using 1H and 13C NMR spectroscopy, IR spectroscopy, MS, and EA. A micro-well dilution assay was used to determine the minimum inhibitory concentration (MIC), and minimum bactericidal concentration. of evaluated compounds. Streptomycin and chloramphenicol were used as a positive control. The best activity of all tested bacteria was observed against E. coli, with a MIC value of 1.25 mg/mL, for complexes with 2,4- i 2,5-pyridinedicarboxylic ligands. Also, all synthesized complexes showed the same activity against C. Albicans.

Kompleksi metala retko se koriste kao potencijalni antimikrobni agensi. U ovom radu smo prikazali sintezu, hemijsku karakterizaciju i antimikrobnu aktivnost 14 arenskih Ru(II) kompleksa sa piridinskim ligandima. Strukturu i čistoću dobijenih jedinjenja potvrdili smo koristeći 1H, 13C NMR i IC spektroskopiju, MS i EA. Mikrodilucioni esej je korišćen za određivanje minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne koncentracije sintetisanih jedinjenja. Streptomicin i hloramfenikol su korišćeni kao standard. Najbolja aktivnost prema ispitivanim sojevima bakterija zapažena je na soju E. coli, sa MIC vrednošću 1,25 mg/mL, kompleksa sa 2,4- i 2,5-piridindikarboksilnim ligandima. Svi sintetisani kompleksi pokazali su podjednako dobru aktivnost prema C. Albicans.