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The Effect of Phenyl Substituents on C-13 NMR Shifts and Metal Ions Binding to 4-Phenyl-2,4-Dioxobutanoic Acid Derivatives
dc.creator | Verbić, Tatjana | |
dc.creator | Drakulić, Branko J. | |
dc.creator | Zloh, Mire | |
dc.creator | Juranić, Ivan O. | |
dc.date.accessioned | 2018-11-22T00:12:32Z | |
dc.date.available | 2018-11-22T00:12:32Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1570-1786 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/595 | |
dc.description.abstract | Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alkyl substituted compounds, was observed. This observation might have pharmacological implications. | en |
dc.publisher | Bentham Science Publ Ltd, Sharjah | |
dc.rights | restrictedAccess | |
dc.source | Letters in Organic Chemistry | |
dc.subject | 4-Aryl-2,4-dioxobutanoic acids | en |
dc.subject | Linear free energy relationships | en |
dc.subject | NMR | en |
dc.subject | MS | en |
dc.subject | UV/VIS spectroscopy | en |
dc.subject | metal complexation ability | en |
dc.title | The Effect of Phenyl Substituents on C-13 NMR Shifts and Metal Ions Binding to 4-Phenyl-2,4-Dioxobutanoic Acid Derivatives | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вербић, Татјана; Злох, Мире; Дракулиц, Бранко Ј.; Јураниц, Иван О.; | |
dc.citation.volume | 5 | |
dc.citation.issue | 8 | |
dc.citation.spage | 692 | |
dc.citation.epage | 699 | |
dc.identifier.wos | 000261926400017 | |
dc.identifier.doi | 10.2174/157017808786857589 | |
dc.citation.other | 5(8): 692-699 | |
dc.citation.rank | M23 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-70349624346 |
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