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pH-Dependent solubility profile of nortriptyline hydrochloride
dc.creator | Marković, Olivera S. | |
dc.creator | Marjanović, Nemanja Ž. | |
dc.creator | Patel, Nirali | |
dc.creator | Serajuddin, Abu T. M. | |
dc.creator | Avdeef, Alex | |
dc.creator | Verbić, Tatjana | |
dc.date.accessioned | 2023-08-24T12:00:46Z | |
dc.date.available | 2023-08-24T12:00:46Z | |
dc.date.issued | 2021 | |
dc.identifier.isbn | 978-86-7132-077-1 | |
dc.identifier.uri | http://cherry.chem.bg.ac.rs/handle/123456789/5962 | |
dc.description.abstract | Solubility is important physicochemical parameter and determines drug stability, bioavailability and therapeutic action. The aim of this study was to examine solubility of nortriptyline hydrochloride in a wide pH range, using pH-Ramp Shake-Flask method, already applied to desipramine hydrochloride [1] and based of recently published recommendations [2]. Solubility was measured in phosphate buffer, in chloride-free media and phoshate-free media, using both nortriptyline base and nortriptyline hydrochloride as starting material. Elemental analysis, termogravimetric analysis, differential scaning calorimetric analysis and powder X-ray diffraction analysis were used for solid precipitate analysis. | sr |
dc.description.abstract | Rastvorljivost je značajno fizičko-hemijsko svojstvo biološki aktivnih i potencijalno biološki aktivnih supstancija, koje određuje stabilnost, biodostupnost i terapeutsko dejstvo leka. Cilj ovog rada je ispitivanje rastvorljivosti nortriptilin-hidrohlorida, pomoću pH-Ramp Shake-Flask metode, prethodno primenjene na desipramin-hidrohlorid [1]. Eksperimenti su izvedeni prema novim preporukama iz literature [2]. Rastvorljivost je određena u fosfatnom puferu, u sistemu bez hlorida i sistemu bez fosfata, koristeći nortriptilin bazu i nortriptilin-hidrohlorid. Urađena je i katakterizacija čvrste faze pomoću elementalne analize, termogravimetrije, diferencijalne skenirajuće kalorimetrije i difrakcije X-zraka. | sr |
dc.language.iso | sr | sr |
dc.language.iso | en | sr |
dc.publisher | Belgrade : Serbian Chemical Society | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | 57th Meeting of the Serbian chemical Society - Proceedings / 57. Savetovanje Srpskog hemijskog društva - Knjiga radova, Kragujevac, Serbia, June 18-19, 2021 | sr |
dc.title | pH-Dependent solubility profile of nortriptyline hydrochloride | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.spage | 32 | |
dc.citation.epage | 32 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | http://cherry.chem.bg.ac.rs/bitstream/id/32753/bitstream_32753.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cherry_5962 |