Bilirubin Interactions with Different Proteins and Implications of These Interactions
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2022
Book part (Published version)

Nova Science Publishers, Inc.
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Bilirubin is a tetrapyrrole, yellow pigment, and it is a degradation productcreated in heme metabolism. This molecule is predominantly present inits unconjugated form in circulation, and it is mainly bound to humanserum albumin. The presence of small amounts of free, unconjugatedbilirubin enables its interactions with other circulation components. Inconditions like Gilbert syndrome or diabetes, the concentration ofunconjugated bilirubin increases in the blood, making other interactingpartners from circulation more important for its metabolism. In the liver,bilirubin is converted to conjugated form, which is then excreted fromthe organism. While the significant increase of bilirubin is toxic, researchsuggests that small increases may be beneficial since bilirubin hasantioxidative and anticancer potential. In this chapter, interactions ofbilirubin with several proteins will be described together with the effectsof these interactions on the protein’s structure and function.
Keywords:
bilirubin / protein binding / metabolism / phycocyanobilinSource:
Advances in Biology, 2022, 1, 85-122Publisher:
- New York: Nova Science Publishers, Inc.
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200019 (University of Belgrade, Institute for the Application of Nuclear Energy - INEP) (RS-200019)
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Hemijski fakultet / Faculty of ChemistryTY - CHAP AU - Gligorijević, Nikola AU - Minić, Simeon PY - 2022 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5985 AB - Bilirubin is a tetrapyrrole, yellow pigment, and it is a degradation productcreated in heme metabolism. This molecule is predominantly present inits unconjugated form in circulation, and it is mainly bound to humanserum albumin. The presence of small amounts of free, unconjugatedbilirubin enables its interactions with other circulation components. Inconditions like Gilbert syndrome or diabetes, the concentration ofunconjugated bilirubin increases in the blood, making other interactingpartners from circulation more important for its metabolism. In the liver,bilirubin is converted to conjugated form, which is then excreted fromthe organism. While the significant increase of bilirubin is toxic, researchsuggests that small increases may be beneficial since bilirubin hasantioxidative and anticancer potential. In this chapter, interactions ofbilirubin with several proteins will be described together with the effectsof these interactions on the protein’s structure and function. PB - New York: Nova Science Publishers, Inc. T2 - Advances in Biology T1 - Bilirubin Interactions with Different Proteins and Implications of These Interactions VL - 1 SP - 85 EP - 122 UR - https://hdl.handle.net/21.15107/rcub_cer_6486 ER -
@inbook{ author = "Gligorijević, Nikola and Minić, Simeon", year = "2022", abstract = "Bilirubin is a tetrapyrrole, yellow pigment, and it is a degradation productcreated in heme metabolism. This molecule is predominantly present inits unconjugated form in circulation, and it is mainly bound to humanserum albumin. The presence of small amounts of free, unconjugatedbilirubin enables its interactions with other circulation components. Inconditions like Gilbert syndrome or diabetes, the concentration ofunconjugated bilirubin increases in the blood, making other interactingpartners from circulation more important for its metabolism. In the liver,bilirubin is converted to conjugated form, which is then excreted fromthe organism. While the significant increase of bilirubin is toxic, researchsuggests that small increases may be beneficial since bilirubin hasantioxidative and anticancer potential. In this chapter, interactions ofbilirubin with several proteins will be described together with the effectsof these interactions on the protein’s structure and function.", publisher = "New York: Nova Science Publishers, Inc.", journal = "Advances in Biology", booktitle = "Bilirubin Interactions with Different Proteins and Implications of These Interactions", volume = "1", pages = "85-122", url = "https://hdl.handle.net/21.15107/rcub_cer_6486" }
Gligorijević, N.,& Minić, S.. (2022). Bilirubin Interactions with Different Proteins and Implications of These Interactions. in Advances in Biology New York: Nova Science Publishers, Inc.., 1, 85-122. https://hdl.handle.net/21.15107/rcub_cer_6486
Gligorijević N, Minić S. Bilirubin Interactions with Different Proteins and Implications of These Interactions. in Advances in Biology. 2022;1:85-122. https://hdl.handle.net/21.15107/rcub_cer_6486 .
Gligorijević, Nikola, Minić, Simeon, "Bilirubin Interactions with Different Proteins and Implications of These Interactions" in Advances in Biology, 1 (2022):85-122, https://hdl.handle.net/21.15107/rcub_cer_6486 .