Sintetisan je novi kompleks Pd(II) sa bphaOEt ligandom koji predstavlja kondenzacioni derivat etil hidrazinoacetata i 2-benzoilpiridina. Kompleks je dobijen templatnom reakcijom polazeći od navedenih reaktanata i K2[PdCl4] u smeši etanol/voda. Sastav novodobijenog kompleksa utvrđen je elementalnom analizom, dok je merenjem molarne provodljivosti utvrđeno da je u pitanju neelektrolit. Uzimajući u obzir navedeno pretpostavljena formula kompleksa je [PdCl2(bphaOEt)]. Kompleks je dijamagnetičan, što odgovara kvadratno-planarnoj geometriji oko Pd(II) jona. Poređenjem 1H i 13C NMR spektralnih podataka za novi kompleks sa podacima za dobijenim za komplekse Pd(II) sa strukturno sličnim
N-heteroaromatičnin derivatima etil hidrazinoacetata, utvrđeno je da je bphaOEt ligand bidentatno koordinovan za metal preko iminskog i piridinskog atoma azota. Treće i četvrto koordinaciono mesto zauzimaju joni hlora. Sintetisani kompleks predstavlja strukturni Pd(II) analog cisplatine. Stoga će dalja istraži...vanja biti usmerena ka ispitivanju biološkog dejstva ovog kompleksa, posebno njegovog citotoksičnog dejstva.
Novel Pd(II) complex with bphaOEt ligand, the condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine, was synthesized by template reaction of the reactants and K2[PdCl4] in ethanol/water mixture. The composition of the complex was obtained by elemental analysis, while molar conductivity measurements showed that the complex is non-electrolyte. Based on these data the formula [PdCl2(bphaOEt)] of the complex can be anticipated. The complex is diamagnetic in nature with square-planar geometry around Pd(II). Comparison of 1H and 13C NMR spectral data for the novel complex with the data obtained for other Pd(II) complexes, with structurally similar
N-heteroaromatic derivatives of ethyl hydrazinoacetate, showed that the ligand bphaOEt is bidentately coordinated to Pd(II) via pyridine and imine nitrogen atoms. Other two coordination sites are occupied by chlorido ligands. The obtained complex represents Pd(II) structural analog of cisplatin. Thus our further research will fo...cus on evaluation of biological activity of novel complex, especially cytotoxic activity.
Source:
Third Conference of Young Chemists of Serbia, Belgrade, Serbia, October 24, 2015, 2015
TY - CONF
AU - Araškov, Jovana
AU - Filipović, Nenad
AU - Todorović, Tamara
PY - 2015
UR - http://cherry.chem.bg.ac.rs/handle/123456789/5995
AB - Sintetisan je novi kompleks Pd(II) sa bphaOEt ligandom koji predstavlja kondenzacioni derivat etil hidrazinoacetata i 2-benzoilpiridina. Kompleks je dobijen templatnom reakcijom polazeći od navedenih reaktanata i K2[PdCl4] u smeši etanol/voda. Sastav novodobijenog kompleksa utvrđen je elementalnom analizom, dok je merenjem molarne provodljivosti utvrđeno da je u pitanju neelektrolit. Uzimajući u obzir navedeno pretpostavljena formula kompleksa je [PdCl2(bphaOEt)]. Kompleks je dijamagnetičan, što odgovara kvadratno-planarnoj geometriji oko Pd(II) jona. Poređenjem 1H i 13C NMR spektralnih podataka za novi kompleks sa podacima za dobijenim za komplekse Pd(II) sa strukturno sličnim
N-heteroaromatičnin derivatima etil hidrazinoacetata, utvrđeno je da je bphaOEt ligand bidentatno koordinovan za metal preko iminskog i piridinskog atoma azota. Treće i četvrto koordinaciono mesto zauzimaju joni hlora. Sintetisani kompleks predstavlja strukturni Pd(II) analog cisplatine. Stoga će dalja istraživanja biti usmerena ka ispitivanju biološkog dejstva ovog kompleksa, posebno njegovog citotoksičnog dejstva.
AB - Novel Pd(II) complex with bphaOEt ligand, the condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine, was synthesized by template reaction of the reactants and K2[PdCl4] in ethanol/water mixture. The composition of the complex was obtained by elemental analysis, while molar conductivity measurements showed that the complex is non-electrolyte. Based on these data the formula [PdCl2(bphaOEt)] of the complex can be anticipated. The complex is diamagnetic in nature with square-planar geometry around Pd(II). Comparison of 1H and 13C NMR spectral data for the novel complex with the data obtained for other Pd(II) complexes, with structurally similar
N-heteroaromatic derivatives of ethyl hydrazinoacetate, showed that the ligand bphaOEt is bidentately coordinated to Pd(II) via pyridine and imine nitrogen atoms. Other two coordination sites are occupied by chlorido ligands. The obtained complex represents Pd(II) structural analog of cisplatin. Thus our further research will focus on evaluation of biological activity of novel complex, especially cytotoxic activity.
PB - Belgrade : Serbian Chemical Society
C3 - Third Conference of Young Chemists of Serbia, Belgrade, Serbia, October 24, 2015
T1 - Synthesis and characterization of palladium(II) complex with condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine
UR - https://hdl.handle.net/21.15107/rcub_cherry_5995
ER -
@conference{
author = "Araškov, Jovana and Filipović, Nenad and Todorović, Tamara",
year = "2015",
abstract = "Sintetisan je novi kompleks Pd(II) sa bphaOEt ligandom koji predstavlja kondenzacioni derivat etil hidrazinoacetata i 2-benzoilpiridina. Kompleks je dobijen templatnom reakcijom polazeći od navedenih reaktanata i K2[PdCl4] u smeši etanol/voda. Sastav novodobijenog kompleksa utvrđen je elementalnom analizom, dok je merenjem molarne provodljivosti utvrđeno da je u pitanju neelektrolit. Uzimajući u obzir navedeno pretpostavljena formula kompleksa je [PdCl2(bphaOEt)]. Kompleks je dijamagnetičan, što odgovara kvadratno-planarnoj geometriji oko Pd(II) jona. Poređenjem 1H i 13C NMR spektralnih podataka za novi kompleks sa podacima za dobijenim za komplekse Pd(II) sa strukturno sličnim
N-heteroaromatičnin derivatima etil hidrazinoacetata, utvrđeno je da je bphaOEt ligand bidentatno koordinovan za metal preko iminskog i piridinskog atoma azota. Treće i četvrto koordinaciono mesto zauzimaju joni hlora. Sintetisani kompleks predstavlja strukturni Pd(II) analog cisplatine. Stoga će dalja istraživanja biti usmerena ka ispitivanju biološkog dejstva ovog kompleksa, posebno njegovog citotoksičnog dejstva., Novel Pd(II) complex with bphaOEt ligand, the condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine, was synthesized by template reaction of the reactants and K2[PdCl4] in ethanol/water mixture. The composition of the complex was obtained by elemental analysis, while molar conductivity measurements showed that the complex is non-electrolyte. Based on these data the formula [PdCl2(bphaOEt)] of the complex can be anticipated. The complex is diamagnetic in nature with square-planar geometry around Pd(II). Comparison of 1H and 13C NMR spectral data for the novel complex with the data obtained for other Pd(II) complexes, with structurally similar
N-heteroaromatic derivatives of ethyl hydrazinoacetate, showed that the ligand bphaOEt is bidentately coordinated to Pd(II) via pyridine and imine nitrogen atoms. Other two coordination sites are occupied by chlorido ligands. The obtained complex represents Pd(II) structural analog of cisplatin. Thus our further research will focus on evaluation of biological activity of novel complex, especially cytotoxic activity.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Third Conference of Young Chemists of Serbia, Belgrade, Serbia, October 24, 2015",
title = "Synthesis and characterization of palladium(II) complex with condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5995"
}
Araškov, J., Filipović, N.,& Todorović, T.. (2015). Synthesis and characterization of palladium(II) complex with condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine. in Third Conference of Young Chemists of Serbia, Belgrade, Serbia, October 24, 2015
Belgrade : Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_cherry_5995
Araškov J, Filipović N, Todorović T. Synthesis and characterization of palladium(II) complex with condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine. in Third Conference of Young Chemists of Serbia, Belgrade, Serbia, October 24, 2015. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_5995 .
Araškov, Jovana, Filipović, Nenad, Todorović, Tamara, "Synthesis and characterization of palladium(II) complex with condensation derivative of ethyl hydrazinoacetate and 2-benzoylpyridine" in Third Conference of Young Chemists of Serbia, Belgrade, Serbia, October 24, 2015 (2015),
https://hdl.handle.net/21.15107/rcub_cherry_5995 .
