One-Step Conversion of Ketones to Conjugated Acids Using Bromoform
AuthorsVitnik, V. D.
Vitnik, Z. J.
Dordevic, J. B.
Zizak, Z. S.
Juranic, Z. D.
Juranić, Ivan O.
Article (Published version)
MetadataShow full item record
Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of alpha,beta-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conjugated acids were obtained from cyclic or aromatic ketones, whereas bromo acids were obtained from 4-oxo-piperidine-1-carboxylic acid ethyl ester (13) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (14).
Keywords:Bromoform / phase-transfer-catalyzed reaction / -unsaturated carboxylic acids
Source:Synthetic Communications, 2009, 39, 8, 1457-1471
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