Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine
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2009
Authors
Mitić, DraganaMilenković, Marina
Milosavljević, Slobodan M.
Gođevac, Dejan
Miodragović, Zoran
Anđelković, Katarina K.
Miodragović Đenana U.
Article (Published version)
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In this paper the first complexes of M(2+) ions (M(2+) = Zn(2+), Cd(2+) and Co(2+)) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and (1)H, (13)C and (15)N NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. alb...icans. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords:
Antimicrobial activity / Co(II), Zn(II), Cd(II) complexes / N-Benzyloxycarbonyl-S-phenylalanine / 2D NMRSource:
European Journal of Medicinal Chemistry, 2009, 44, 4, 1537-1544Publisher:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Funding / projects:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-MESTD-MPN2006-2010-142062)
DOI: 10.1016/j.ejmech.2008.07.017
ISSN: 0223-5234
PubMed: 18760509
WoS: 000264920000018
Scopus: 2-s2.0-61549109905
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mitić, Dragana AU - Milenković, Marina AU - Milosavljević, Slobodan M. AU - Gođevac, Dejan AU - Miodragović, Zoran AU - Anđelković, Katarina K. AU - Miodragović Đenana U. PY - 2009 UR - https://cherry.chem.bg.ac.rs/handle/123456789/624 AB - In this paper the first complexes of M(2+) ions (M(2+) = Zn(2+), Cd(2+) and Co(2+)) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and (1)H, (13)C and (15)N NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans. (C) 2008 Elsevier Masson SAS. All rights reserved. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris T2 - European Journal of Medicinal Chemistry T1 - Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine VL - 44 IS - 4 SP - 1537 EP - 1544 DO - 10.1016/j.ejmech.2008.07.017 ER -
@article{ author = "Mitić, Dragana and Milenković, Marina and Milosavljević, Slobodan M. and Gođevac, Dejan and Miodragović, Zoran and Anđelković, Katarina K. and Miodragović Đenana U.", year = "2009", abstract = "In this paper the first complexes of M(2+) ions (M(2+) = Zn(2+), Cd(2+) and Co(2+)) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and (1)H, (13)C and (15)N NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans. (C) 2008 Elsevier Masson SAS. All rights reserved.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris", journal = "European Journal of Medicinal Chemistry", title = "Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine", volume = "44", number = "4", pages = "1537-1544", doi = "10.1016/j.ejmech.2008.07.017" }
Mitić, D., Milenković, M., Milosavljević, S. M., Gođevac, D., Miodragović, Z., Anđelković, K. K.,& Miodragović Đenana U.. (2009). Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 44(4), 1537-1544. https://doi.org/10.1016/j.ejmech.2008.07.017
Mitić D, Milenković M, Milosavljević SM, Gođevac D, Miodragović Z, Anđelković KK, Miodragović Đenana U.. Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine. in European Journal of Medicinal Chemistry. 2009;44(4):1537-1544. doi:10.1016/j.ejmech.2008.07.017 .
Mitić, Dragana, Milenković, Marina, Milosavljević, Slobodan M., Gođevac, Dejan, Miodragović, Zoran, Anđelković, Katarina K., Miodragović Đenana U., "Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1537-1544, https://doi.org/10.1016/j.ejmech.2008.07.017 . .