Faculty of Chemistry Repository - Cherry
University of Belgrade - Faculty of Chemistry
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Faculty of Chemistry Repository - Cherry
  • Hemijski fakultet
  • Publikacije
  • View Item
  •   Faculty of Chemistry Repository - Cherry
  • Hemijski fakultet
  • Publikacije
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity

Authorized Users Only
2009
Authors
Rakic, Gordana M.
Grgurić-Šipka, Sanja
Kaluđerović, Goran N.
Gomez-Ruiz, Santiago
Bjelogrlić, Snežana K.
Radulović, Siniša
Tešić, Živoslav Lj.
Article (Published version)
Metadata
Show full item record
Abstract
Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords:
Platinum(II) / Antitumoral activity / DFT / X-ray
Source:
European Journal of Medicinal Chemistry, 2009, 44, 5, 1921-1925
Publisher:
  • Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Projects:
  • Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-142010)
  • Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)
  • Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji (RS-145035)

DOI: 10.1016/j.ejmech.2008.11.004

ISSN: 0223-5234

PubMed: 19070943

WoS: 000265339900012

Scopus: 2-s2.0-62749093668
[ Google Scholar ]
21
19
URI
http://cherry.chem.bg.ac.rs/handle/123456789/630
Collections
  • Publikacije
Institution
Hemijski fakultet

DSpace software copyright © 2002-2015  DuraSpace
About CHERRY - CHEmistry RepositoRY | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CHERRY - CHEmistry RepositoRY | Send Feedback

OpenAIRERCUB