Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity
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2009
Authors
Rakic, Gordana M.Grgurić-Šipka, Sanja

Kaluđerović, Goran N.

Gomez-Ruiz, Santiago

Bjelogrlić, Snežana K.

Radulović, Siniša

Tešić, Živoslav Lj.

Article (Published version)

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Show full item recordAbstract
Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords:
Platinum(II) / Antitumoral activity / DFT / X-raySource:
European Journal of Medicinal Chemistry, 2009, 44, 5, 1921-1925Publisher:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Projects:
- Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-142010)
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)
- Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji (RS-145035)
DOI: 10.1016/j.ejmech.2008.11.004
ISSN: 0223-5234
PubMed: 19070943