Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords:
Platinum(II) / Antitumoral activity / DFT / X-ray
Source:
European Journal of Medicinal Chemistry, 2009, 44, 5, 1921-1925
Publisher:
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
TY - JOUR
AU - Rakic, Gordana M.
AU - Grgurić-Šipka, Sanja
AU - Kaluđerović, Goran N.
AU - Gomez-Ruiz, Santiago
AU - Bjelogrlić, Snežana K.
AU - Radulović, Siniša
AU - Tešić, Živoslav Lj.
PY - 2009
UR - https://cherry.chem.bg.ac.rs/handle/123456789/630
AB - Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.
PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2 - European Journal of Medicinal Chemistry
T1 - Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity
VL - 44
IS - 5
SP - 1921
EP - 1925
DO - 10.1016/j.ejmech.2008.11.004
UR - Kon_1979
ER -
@article{
author = "Rakic, Gordana M. and Grgurić-Šipka, Sanja and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Bjelogrlić, Snežana K. and Radulović, Siniša and Tešić, Živoslav Lj.",
year = "2009",
abstract = "Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity",
volume = "44",
number = "5",
pages = "1921-1925",
doi = "10.1016/j.ejmech.2008.11.004",
url = "Kon_1979"
}
Rakic, G. M., Grgurić-Šipka, S., Kaluđerović, G. N., Gomez-Ruiz, S., Bjelogrlić, S. K., Radulović, S.,& Tešić, Ž. Lj.. (2009). Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 44(5), 1921-1925.
https://doi.org/10.1016/j.ejmech.2008.11.004
Kon_1979
Rakic GM, Grgurić-Šipka S, Kaluđerović GN, Gomez-Ruiz S, Bjelogrlić SK, Radulović S, Tešić ŽL. Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity. in European Journal of Medicinal Chemistry. 2009;44(5):1921-1925.
doi:10.1016/j.ejmech.2008.11.004
Kon_1979 .
Rakic, Gordana M., Grgurić-Šipka, Sanja, Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Bjelogrlić, Snežana K., Radulović, Siniša, Tešić, Živoslav Lj., "Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity" in European Journal of Medicinal Chemistry, 44, no. 5 (2009):1921-1925,
https://doi.org/10.1016/j.ejmech.2008.11.004 .,
Kon_1979 .
