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dc.creatorRakic, Gordana M.
dc.creatorGrgurić-Šipka, Sanja
dc.creatorKaluđerović, Goran N.
dc.creatorGomez-Ruiz, Santiago
dc.creatorBjelogrlić, Snežana K.
dc.creatorRadulović, Siniša
dc.creatorTešić, Živoslav Lj.
dc.date.accessioned2018-11-22T00:14:33Z
dc.date.available2018-11-22T00:14:33Z
dc.date.issued2009
dc.identifier.issn0223-5234
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/630
dc.description.abstractNovel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145035/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectPlatinum(II)en
dc.subjectAntitumoral activityen
dc.subjectDFTen
dc.subjectX-rayen
dc.titleNovel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКалудеровиц, Горан Н.; Гргурић-Шипка, Сања; Ракиц, Гордана М.; Радуловиц, Синиса С.; Тешић, Живослав Љ.; Гомез-Руиз, Сантиаго; Бјелогрлиц, Снезана К.;
dc.citation.volume44
dc.citation.issue5
dc.citation.spage1921
dc.citation.epage1925
dc.identifier.wos000265339900012
dc.identifier.doi10.1016/j.ejmech.2008.11.004
dc.citation.other44(5): 1921-1925
dc.citation.rankM21
dc.identifier.pmid19070943
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-62749093668
dc.identifier.rcubKon_1979


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