Regioselective reduction of 5-substituted 2-alkylidene-4-oxothiazolidines by metal hydrides
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Thiazolidine beta-enamino derivatives possessing a 5-substituted acetate substituent were chemoselectively reduced to corresponding alcohols, or new condensed 2-alkylidenethiazolidines. The method is based on the resistance of an enaminone fragment to reduction by metal hydrides.
Keywords:thiazolidine / reductions / hydrides / regioselectivity / ring closure
Source:Synlett, 2004, 6, 1034-1038
- Georg Thieme Verlag Kg, Stuttgart