DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper
Аутори
Mijatović, AleksandarCakovic, Angelina
Lolić, Aleksandar
Sretenovic, Snezana
Zivanovic, Marko
Petrović, Biljana
Bogojeski, Jovana
Seklic, Dragana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on ...both cell lines, while complexes 1 and 3 did not show any activity.
Кључне речи:
antitumor / mechanism / cell line / biomolecule / affinity / drug designИзвор:
Journal of the Serbian Chemical Society, 2023, 88, 12, 1307-1317Издавач:
- Serbian Chemical Society
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200122 (Универзитет у Крагујевцу, Природно-математички факултет) (RS-MESTD-inst-2020-200122)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200126 (Универзитет у Београду, Рударско-геолошки факултет) (RS-MESTD-inst-2020-200126)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200126 (Универзитет у Београду, Рударско-геолошки факултет) (RS-MESTD-inst-2020-200126)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200125 (Универзитет у Новом Саду, Природно-математички факултет) (RS-MESTD-inst-2020-200125)
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mijatović, Aleksandar AU - Cakovic, Angelina AU - Lolić, Aleksandar AU - Sretenovic, Snezana AU - Zivanovic, Marko AU - Petrović, Biljana AU - Bogojeski, Jovana AU - Seklic, Dragana PY - 2023 UR - http://cherry.chem.bg.ac.rs/handle/123456789/6458 AB - Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper VL - 88 IS - 12 SP - 1307 EP - 1317 DO - 10.2298/JSC230614063M ER -
@article{ author = "Mijatović, Aleksandar and Cakovic, Angelina and Lolić, Aleksandar and Sretenovic, Snezana and Zivanovic, Marko and Petrović, Biljana and Bogojeski, Jovana and Seklic, Dragana", year = "2023", abstract = "Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)propylenediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(benzoylacetone)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectroscopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA intercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper", volume = "88", number = "12", pages = "1307-1317", doi = "10.2298/JSC230614063M" }
Mijatović, A., Cakovic, A., Lolić, A., Sretenovic, S., Zivanovic, M., Petrović, B., Bogojeski, J.,& Seklic, D.. (2023). DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper. in Journal of the Serbian Chemical Society Serbian Chemical Society., 88(12), 1307-1317. https://doi.org/10.2298/JSC230614063M
Mijatović A, Cakovic A, Lolić A, Sretenovic S, Zivanovic M, Petrović B, Bogojeski J, Seklic D. DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(12):1307-1317. doi:10.2298/JSC230614063M .
Mijatović, Aleksandar, Cakovic, Angelina, Lolić, Aleksandar, Sretenovic, Snezana, Zivanovic, Marko, Petrović, Biljana, Bogojeski, Jovana, Seklic, Dragana, "DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 12 (2023):1307-1317, https://doi.org/10.2298/JSC230614063M . .