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Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
dc.creator | Tomic, M | |
dc.creator | Kundakovic, M | |
dc.creator | Butorovi, B | |
dc.creator | Janac, B | |
dc.creator | Andrić, Deana | |
dc.creator | Roglić, Goran | |
dc.creator | Ignjatović, Đurđica | |
dc.creator | Kostić-Rajačić, Slađana | |
dc.date.accessioned | 2018-11-22T00:07:13Z | |
dc.date.available | 2018-11-22T00:07:13Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/652 | |
dc.description.abstract | Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics ( gt 1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. (C) 2004 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry Letters | |
dc.subject | arylpiperazine | en |
dc.subject | dopamine receptors | en |
dc.subject | serotonin receptors | en |
dc.subject | atypical antipsychotic | en |
dc.title | Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Костиц-Рајациц, С; Кундаковиц, М; Томиц, М; Игњатовиц, Д; Aндрић, Деана; Буторови, Б; Јанац, Б; Роглић, Горан; | |
dc.citation.volume | 14 | |
dc.citation.issue | 16 | |
dc.citation.spage | 4263 | |
dc.citation.epage | 4266 | |
dc.identifier.wos | 000222923300029 | |
dc.identifier.doi | 10.1016/j.bmcl.2004.06.005 | |
dc.citation.other | 14(16): 4263-4266 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 15261283 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-3142691095 |