Stereoselective synthesis of alpha-hydroxy-beta-amino acids: the chiral pool approach
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A method for the stereoselective homologation of alpha-amino acids into syn-alpha-hydroxy-beta-amino acids is described. based on the conversion of stereoisomeric cyanohydrins into trans-oxazolines. The synthetic potential of the method is illustrated in the enantioselective formal synthesis of Bestatin.
Keywords:amino acids / cyanohydrins / bestatin / AHPA / oxazoline
Source:Journal of the Serbian Chemical Society, 2004, 69, 11, 981-990
- Serbian Chemical Soc, Belgrade