Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N '-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC
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2005
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This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [II], dichlorodiiodo(O,O-ii-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [III], and dichloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(II) [V] complexes, with the formulae [Pt(dbeddp)Br3Cl], [Pt(dbeddp)Cl2I2] and [Pt(dbeddp)Cl-2], respectively. The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy and electrospray mass spectrometry. In the aim to assess the selectivity in the antitumor action of these complexes, as well, as tetrachloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [I] and tetrachloro(O,O-n-pentyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [IV], the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells, to human myelogenous leukemia K562 cells and to normal immunocompetent cells, i.e., on human peripheral bloo...d mononuclear PBMC cells. (C) 2004 Elsevier Inc. All rights reserved.
Ključne reči:
platinum(IV) complexes / Eddp / neoplastic cells / PBMCIzvor:
Journal of Inorganic Biochemistry, 2005, 99, 2, 488-496Izdavač:
- Elsevier Science Inc, New York
DOI: 10.1016/j.jinorgbio.2004.10.025
ISSN: 0162-0134
PubMed: 15621281
WoS: 000226392400015
Scopus: 2-s2.0-11144318782
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Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Kaluđerović, Goran N. AU - Dinovic, VM AU - Juranic, ZD AU - Stanojković, Tatjana AU - Sabo, Tibor PY - 2005 UR - https://cherry.chem.bg.ac.rs/handle/123456789/685 AB - This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [II], dichlorodiiodo(O,O-ii-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [III], and dichloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(II) [V] complexes, with the formulae [Pt(dbeddp)Br3Cl], [Pt(dbeddp)Cl2I2] and [Pt(dbeddp)Cl-2], respectively. The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy and electrospray mass spectrometry. In the aim to assess the selectivity in the antitumor action of these complexes, as well, as tetrachloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [I] and tetrachloro(O,O-n-pentyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [IV], the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells, to human myelogenous leukemia K562 cells and to normal immunocompetent cells, i.e., on human peripheral blood mononuclear PBMC cells. (C) 2004 Elsevier Inc. All rights reserved. PB - Elsevier Science Inc, New York T2 - Journal of Inorganic Biochemistry T1 - Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N '-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC VL - 99 IS - 2 SP - 488 EP - 496 DO - 10.1016/j.jinorgbio.2004.10.025 ER -
@article{ author = "Kaluđerović, Goran N. and Dinovic, VM and Juranic, ZD and Stanojković, Tatjana and Sabo, Tibor", year = "2005", abstract = "This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [II], dichlorodiiodo(O,O-ii-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [III], and dichloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(II) [V] complexes, with the formulae [Pt(dbeddp)Br3Cl], [Pt(dbeddp)Cl2I2] and [Pt(dbeddp)Cl-2], respectively. The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy and electrospray mass spectrometry. In the aim to assess the selectivity in the antitumor action of these complexes, as well, as tetrachloro(O,O-n-butyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [I] and tetrachloro(O,O-n-pentyl-ethylenediamine-N,N'-di-3-propanoate)platinum(IV) [IV], the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells, to human myelogenous leukemia K562 cells and to normal immunocompetent cells, i.e., on human peripheral blood mononuclear PBMC cells. (C) 2004 Elsevier Inc. All rights reserved.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Inorganic Biochemistry", title = "Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N '-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC", volume = "99", number = "2", pages = "488-496", doi = "10.1016/j.jinorgbio.2004.10.025" }
Kaluđerović, G. N., Dinovic, V., Juranic, Z., Stanojković, T.,& Sabo, T.. (2005). Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N '-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC. in Journal of Inorganic Biochemistry Elsevier Science Inc, New York., 99(2), 488-496. https://doi.org/10.1016/j.jinorgbio.2004.10.025
Kaluđerović GN, Dinovic V, Juranic Z, Stanojković T, Sabo T. Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N '-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC. in Journal of Inorganic Biochemistry. 2005;99(2):488-496. doi:10.1016/j.jinorgbio.2004.10.025 .
Kaluđerović, Goran N., Dinovic, VM, Juranic, ZD, Stanojković, Tatjana, Sabo, Tibor, "Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N '-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC" in Journal of Inorganic Biochemistry, 99, no. 2 (2005):488-496, https://doi.org/10.1016/j.jinorgbio.2004.10.025 . .