Приказ основних података о документу
Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC
dc.creator | Sabo, Tibor | |
dc.creator | Dinovic, VA | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Bogdanović, Goran A. | |
dc.creator | Juranic, ZD | |
dc.date.accessioned | 2018-11-22T00:08:09Z | |
dc.date.available | 2018-11-22T00:08:09Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/693 | |
dc.description.abstract | Four platinum(IV) complexes, trans,trans-dichlorobis(N,N-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Cl-2] (1) and trans.trans-dibromobis(N,N'-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Br-2] (2), as well as, trans,trans-dichlorobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Cl-2] (3) and trans,trans-dibromobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Br-2] (4) (with configuration index for all complexes OC-6-14), were synthesized and characterized by elemental analysis, infrared and H-1 NMR spectroscopy. In the aim to assess the selectivity in the antitumor action of these complexes, the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells; to human myelogenous leukemia K562 cells and to normal immunocompetent cells; i.e., on human PBMC. The details of the crystal structure synthesized trans,trans-[Pt(sar)(2)Br-2] complex were also reported here. In the crystal structure of trans, trans-[Pt(sar)(2)Br-2] the Pt(IV) ion had a deformed octahedral coordination with both N-methylglycinates and bromides bonded trans to one another and with the NPt-Br bond angles of 84.1(4) and 95.9(4)degrees. The trans, trans-[Pt(sar)(2)Br-2] complex molecules form 2D-layers with multiple N-H (...) O and C-H (...) O hydrogen bonds. (c) 2005 Elsevier B.V. All rights reserved. | en |
dc.publisher | Elsevier Science Sa, Lausanne | |
dc.rights | restrictedAccess | |
dc.source | Inorganica Chimica Acta | |
dc.subject | platinum (IV) complexes | en |
dc.subject | bidentate ligands | en |
dc.subject | sarcosine | en |
dc.subject | crystal structure | en |
dc.subject | neoplastic cells | en |
dc.subject | PBMC | en |
dc.title | Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Богдановиц, ГA; Калудеровиц, ГН; Станојковиц, ТП; Сабо, Тибор; Диновиц, ВA; Јураниц, ЗД; | |
dc.citation.volume | 358 | |
dc.citation.issue | 7 | |
dc.citation.spage | 2239 | |
dc.citation.epage | 2245 | |
dc.identifier.wos | 000228137700011 | |
dc.identifier.doi | 10.1016/j.ica.2005.01.007 | |
dc.citation.other | 358(7): 2239-2245 | |
dc.citation.rank | M22 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-15044361609 |