Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
Abstract
A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed no activity in the tubulin test. (c) 2005 Elsevier Ltd. All rights reserved.
Keywords:
taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modelingSource:
Tetrahedron Letters, 2005, 46, 30, 5049-5052Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/j.tetlet.2005.05.071
ISSN: 0040-4039