Novel platinum(IV) complexes induce rapid tumor cell death in vitro
Samo za registrovane korisnike
2005
Autori
Kaludjerovic, GNMiljković, Đorđe
Momčilović, Miljana
Djinovic, VM
Stojkovic, MM
Sabo, Tibor
Trajković, Vladimir S.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating thei...r potential usefulness in anticancer therapy. (C) 2005 Wiley-Liss, Inc.
Ključne reči:
platinum(IV) / cisplatin / apoptosis / necrosis / oxidative stressIzvor:
International Journal of Cancer, 2005, 116, 3, 479-486Izdavač:
- Wiley, Hoboken
DOI: 10.1002/ijc.21080
ISSN: 0020-7136
PubMed: 15818622
WoS: 000230466100021
Scopus: 2-s2.0-22244452610
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Kaludjerovic, GN AU - Miljković, Đorđe AU - Momčilović, Miljana AU - Djinovic, VM AU - Stojkovic, MM AU - Sabo, Tibor AU - Trajković, Vladimir S. PY - 2005 UR - https://cherry.chem.bg.ac.rs/handle/123456789/719 AB - The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. (C) 2005 Wiley-Liss, Inc. PB - Wiley, Hoboken T2 - International Journal of Cancer T1 - Novel platinum(IV) complexes induce rapid tumor cell death in vitro VL - 116 IS - 3 SP - 479 EP - 486 DO - 10.1002/ijc.21080 ER -
@article{ author = "Kaludjerovic, GN and Miljković, Đorđe and Momčilović, Miljana and Djinovic, VM and Stojkovic, MM and Sabo, Tibor and Trajković, Vladimir S.", year = "2005", abstract = "The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. (C) 2005 Wiley-Liss, Inc.", publisher = "Wiley, Hoboken", journal = "International Journal of Cancer", title = "Novel platinum(IV) complexes induce rapid tumor cell death in vitro", volume = "116", number = "3", pages = "479-486", doi = "10.1002/ijc.21080" }
Kaludjerovic, G., Miljković, Đ., Momčilović, M., Djinovic, V., Stojkovic, M., Sabo, T.,& Trajković, V. S.. (2005). Novel platinum(IV) complexes induce rapid tumor cell death in vitro. in International Journal of Cancer Wiley, Hoboken., 116(3), 479-486. https://doi.org/10.1002/ijc.21080
Kaludjerovic G, Miljković Đ, Momčilović M, Djinovic V, Stojkovic M, Sabo T, Trajković VS. Novel platinum(IV) complexes induce rapid tumor cell death in vitro. in International Journal of Cancer. 2005;116(3):479-486. doi:10.1002/ijc.21080 .
Kaludjerovic, GN, Miljković, Đorđe, Momčilović, Miljana, Djinovic, VM, Stojkovic, MM, Sabo, Tibor, Trajković, Vladimir S., "Novel platinum(IV) complexes induce rapid tumor cell death in vitro" in International Journal of Cancer, 116, no. 3 (2005):479-486, https://doi.org/10.1002/ijc.21080 . .