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Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography

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Authors
Velickovic, JD
Tešić, Živoslav Lj.
Milojković-Opsenica, Dušanka
Article (Published version)
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Abstract
The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.
Keywords:
lipophilicity / RP-18 / 1-arylpiperazines
Source:
Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2005, 18, 105, 358-363
Publisher:
  • Research Inst Medicinal Plants, Budakalasz

DOI: 10.1556/JPC.18.2005.5.4

ISSN: 0933-4173

WoS: 000233095000004

Scopus: 2-s2.0-27944471861
[ Google Scholar ]
6
6
URI
https://cherry.chem.bg.ac.rs/handle/123456789/737
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Velickovic, JD
AU  - Tešić, Živoslav Lj.
AU  - Milojković-Opsenica, Dušanka
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/737
AB  - The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography
T1  - Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography
VL  - 18
IS  - 105
SP  - 358
EP  - 363
DO  - 10.1556/JPC.18.2005.5.4
UR  - Kon_1690
ER  - 
@article{
author = "Velickovic, JD and Tešić, Živoslav Lj. and Milojković-Opsenica, Dušanka",
year = "2005",
abstract = "The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography",
title = "Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography",
volume = "18",
number = "105",
pages = "358-363",
doi = "10.1556/JPC.18.2005.5.4",
url = "Kon_1690"
}
Velickovic, J., Tešić, Ž. Lj.,& Milojković-Opsenica, D.. (2005). Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography
Research Inst Medicinal Plants, Budakalasz., 18(105), 358-363.
https://doi.org/10.1556/JPC.18.2005.5.4
Kon_1690
Velickovic J, Tešić ŽL, Milojković-Opsenica D. Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography. 2005;18(105):358-363.
doi:10.1556/JPC.18.2005.5.4
Kon_1690 .
Velickovic, JD, Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka, "Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography" in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 18, no. 105 (2005):358-363,
https://doi.org/10.1556/JPC.18.2005.5.4 .,
Kon_1690 .

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