Show simple item record

Uticaj pentobarbitala i pentilenetetrazola na nivo azot oksida u frontalnom korteksu pacova

dc.creatorDzoljic, E
dc.creatorNesic, Z
dc.creatorStojanovic, R
dc.creatorTodorović, Zoran B.
dc.creatorVuckovic, S
dc.creatorDelic, D
dc.creatorIvanović, Milovan
dc.creatorProstran, M
dc.date.accessioned2018-11-22T00:08:58Z
dc.date.available2018-11-22T00:08:58Z
dc.date.issued2005
dc.identifier.issn0567-8315
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/744
dc.description.abstractLevels of nitric oxide (NO) in the rats frontal cortex were continuously monitored before and after intraperitoneal administration of an antiepileptic drug-pentobarbital (20 and 40 mg/kg) or convulsant drug - pentylenetetrazol (50 mg/kg). Pentobarbital decreased the levels of NO in a dose dependent manner However, NO levels had a tendency to increase following the administration of pentylenetetrazol. It is suggested that central NO participates in the modulation of neuronal excitability, supporting the idea that NO is an important excitatory factor involved in the regulation of seizure susceptibility. Also, our results on anaesthetized rats suggests that endogenous NO may be involved in the mechanism of action of antiepileptic and analeptic drugs and this further suggest that NO levels in the human brain may decrease during antiepileptic therapy and increase during epileptic attacks or administration of excitatory drugs. The aim of the present study was to determine the possible role of NO levels in the brain during neuronal excitability and seizures.en
dc.description.abstractNivo azot oksida (NO) u frontalnom korteksu pacova meren je kontinuirano kako pre, tako i nakon intraperitonealne primene antiepileptika pentobarbitala (u dozi od 20 i 40 mg/kg) ili konvulzivnog agensa pentilenetetrazola (u dozi od 50 mg/kg). Rezultati ovih eksperimenta su ukazali da pentobarbital smanjuje nivo NO u frontalnom korteksu pacova, dok koncentracija NO ima tendeciju rasta nakon primene pentilenetetrazola. Osim toga, dokazano je da endogeni NO ima važnu ekscitatornu ulogu u centralnim mehanizmima nastanka epilepsije. Takođe, naši rezultati su ukazali da kod anestetisanih životinja endogeni nivo NO ima uticaja na dejstvo kako antikonvulzivnih, tako i prokonvulzivnih lekova. Nivo NO u mozgu pacova je bio snižen tokom terapije antiepilepticima, a povišen tokom epileptičkih napada ili primene lekova iz grupe centralnih stimulansa.sr
dc.publisherDe Gruyter Open Ltd, Warsaw
dc.rightsopenAccess
dc.sourceActa Veterinaria, Beograd
dc.subjectnitric oxide levelsen
dc.subjectpentobarbitalen
dc.subjectpentobarbitalen
dc.subjectpentylenetetrazolen
dc.subjectpentylenetetrazolen
dc.subjectrat frontal cortexen
dc.subjectrat frontal codexen
dc.titleDifferent effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortexen
dc.titleUticaj pentobarbitala i pentilenetetrazola na nivo azot oksida u frontalnom korteksu pacovasr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДелиц, Д; Дзољиц, Е; Вуцковиц, С; Тодоровиц, З; Стојановиц, Р; Ивановић, Милован; Несиц, З; Простран, М; Утицај пентобарбитала и пентиленететразола на ниво азот оксида у фронталном кортексу пацова; Утицај пентобарбитала и пентиленететразола на ниво азот оксида у фронталном кортексу пацова;
dc.citation.volume55
dc.citation.issue5-6
dc.citation.spage367
dc.citation.epage374
dc.identifier.wos000234035600003
dc.identifier.doi10.2298/AVB0506367D
dc.citation.other55(5-6): 367-374
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-29344474271
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/9969/742.pdf
dc.identifier.rcubKon_1697


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record